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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Familial occurrence of painful subacute thyroiditis associated with human leukocyte antigen-B35
Presse Medicale, Volume 36, No. 5 I, Year 2007
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Description
Introduction: Subacute thyroiditis (SAT) is a spontaneously remitting inflammatory disorder of the thyroid that is presumed to be virally induced in genetically predisposed individuals. A strong association has been suggested between human leukocyte antigen (HLA)-B35 and patients who developed SAT. However, familial occurrence of SAT associated with HLA-B35 is reported only rarely. Case-reports: We report three sibs, (two brothers and one sister) living in the same Lebanese town, who developed SAT during an 18-month-period. All tested positive for HLA-B35. Discussion: The family described here represents the first Third World third familial report of SAT associated with HLA-B35. It highlights the probably underestimated importance of genetic predisposition to SAT in families. © 2007 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Zein, Émile F.
Lebanon, Beirut
Saint Joseph Hospital, Beirut
Karaa, Souheil E.
Lebanon, Beirut
Saint Joseph Hospital, Beirut
Megarbane, Andre
Lebanon, Beirut
Université Saint-joseph de Beyrouth
Statistics
Citations: 17
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.lpm.2007.02.011
ISSN:
07554982
Research Areas
Genetics And Genomics