Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Bacteremia in Malawian children with severe malaria: Prevalence, etiology, HIV coinfection, and outcome
Journal of Infectious Diseases, Volume 195, No. 6, Year 2007
Notification
URL copied to clipboard!
Description
Background. Previous prospective studies of bacteremia in African children with severe malaria have mainly included children with cerebral malaria, and no study has examined the impact of human immunodeficiency virus (HIV) infection. We examined the prevalence and etiology of bacteremia and the impact of HIV infection on bacteremia in Malawian children with severe malaria, as well as the impact of bacteremia and HIV infection on outcome. Methods. From 1996 until 2005, blood for culture was obtained on admission from all children admitted with severe malaria during the rainy season to the Paediatric Research Ward at the Queen Elizabeth Central Hospital in Blantyre, Malawi. HIV testing was performed prospectively from 2001 to 2005 and retrospectively for those admitted from 1996 to 2000. Multivariate regression analysis examined independent risk factors for bacteremia and death. Results. Sixty-four (4.6%) of 1388 children with severe malaria had bacteremia; nontyphoidal Salmonellae (NTS) accounted for 58% of all bacteremias. The prevalence of any bacteremia and of NTS bacteremia was highest in children with severe malarial anemia (11.7% and 7.6%), compared with the prevalence in children with cerebral malaria and severe anemia (4.7% and 3.8%) and in those with cerebral malaria alone (3.0% and 0.9%). HIV infection status was determined in 1119 patients. HIV prevalence was 16% (and was highest in those with severe malaria anemia, at 20.4%), but HIV infection was not significantly associated with bacteremia. Neither bacteremia nor HIV infection was associated with death. Conclusions. Antibiotics are not routinely indicated for children with severe malaria in this region, in which HIV is endemic. However, antibiotic therapy should be used to treat NTS infection if bacteremia is suspected in children with severe malarial anemia. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Bronzan, Rachel N.
Malawi, Zomba
University of Malawi
United States, East Lansing
Michigan State University
Taylor, Terrie Ellen
Malawi, Zomba
University of Malawi
United States, East Lansing
Michigan State University
Mwenechanya, James
Malawi, Zomba
University of Malawi
Tembo, Madalitso
Malawi, Zomba
University of Malawi
Kayira, Kondwani
Malawi, Zomba
University of Malawi
Bwanaisa, Lloyd L.
Malawi, Zomba
University of Malawi
Njobvu, Alfred
Malawi, Zomba
University of Malawi
Kondowe, Wendy
Malawi, Zomba
University of Malawi
Chalira, Chipo
Malawi, Zomba
University of Malawi
Walsh, Amanda L.
Malawi, Zomba
University of Malawi
Phiri, Amos J.
Malawi, Zomba
University of Malawi
Wilson, Lorna K.
Malawi, Zomba
University of Malawi
Molyneux, Malcolm Edward
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Graham, Stephen Michael
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Statistics
Citations: 265
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1086/511437
ISSN:
00221899
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Malawi