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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Early life experiences and trajectories of cognitive development
Pediatrics, Volume 146, No. 3, Article e20193660, Year 2020
Notification
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Description
BACKGROUND: Multiple factors constrain the trajectories of child cognitive development, but the drivers that differentiate the trajectories are unknown. We examine how multiple early life experiences differentiate patterns of cognitive development over the first 5 years of life in low-and middle-income settings. METHODS: Cognitive development of 835 children from the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) multisite observational cohort study was assessed at 6, 15, 24 (Bayley Scales of Infant and Toddler Development), and 60 months (Wechsler Preschool and Primary Scale of Intelligence). Markers of socioeconomic status, infection, illness, dietary intake and status, anthropometry, and maternal factors were also assessed. Trajectories of development were determined by latent class-mixed models, and factors associated with class membership were examined by discriminant analysis. RESULTS: Five trajectory groups of cognitive development are described. The variables that best discriminated between trajectories included presence of stimulating and learning resources in the home, emotional or verbal responsivity of caregiver and the safety of the home environment (especially at 24 and 60 months), proportion of days (0-24 months) for which the child had diarrhea, acute lower respiratory infection, fever or vomiting, maternal reasoning ability, mean nutrient densities of zinc and phytate, and total energy from complementary foods (9-24 months). CONCLUSIONS: A supporting and nurturing environment was the variable most strongly differentiating the most and least preferable trajectories of cognitive development. In addition, a higher quality diet promoted cognitive development while prolonged illness was indicative of less favorable patterns of development. Copyright © 2020 by the American Academy of Pediatrics
Authors & Co-Authors
McCormick, Benjamin J.J.
United States, Bethesda
National Institutes of Health Nih
Caulfield, Laura E.
United States, Baltimore
Johns Hopkins University
Richard, Stephanie A.
United States, Bethesda
National Institutes of Health Nih
Pendergast, Laura L.
United States, Philadelphia
Temple University
Seidman, Jessica C.
United States, Bethesda
National Institutes of Health Nih
Maphula, Angelina
South Africa, Thohoyandou
University of Venda
Koshy, Beena
India, Vellore
Christian Medical College, Vellore
Blacy, Ladislaus
Tanzania, Mbulu
Haydom Lutheran Hospital
Roshan, Reeba
India, Vellore
Christian Medical College, Vellore
Nahar, Baitun
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Shrestha, Rita
Nepal, Kathmandu
Tribhuvan University
Rasheed, Muneera Abdul
Pakistan, Karachi
The Aga Khan University
Svensen, Erling
Tanzania, Mbulu
Haydom Lutheran Hospital
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Rasmussen, Zeba A.
United States, Bethesda
National Institutes of Health Nih
Scharf, Rebecca J.
United States, Charlottesville
University of Virginia
Haque, Sayma
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Oriá, Reinaldo B.
Pakistan, Karachi
The Aga Khan University
Brazil, Fortaleza
Universidade Federal do Ceará
Murray-Kolb, Laura E.
United States, University Park
Pennsylvania State University
Acosta, Angel Mendez
Peru, Lima
Asociacion Benefica Prisma Lima
de Burga, Rosa Rios
Peru, Lima
Asociacion Benefica Prisma Lima
Chávez, Cesar Banda
Peru, Lima
Asociacion Benefica Prisma Lima
Flores, Julian Torres
Peru, Lima
Asociacion Benefica Prisma Lima
Olotegui, Maribel Paredes
Peru, Lima
Asociacion Benefica Prisma Lima
Pinedo, Silvia Rengifo
Peru, Lima
Asociacion Benefica Prisma Lima
Salas, Mery Siguas
Peru, Lima
Asociacion Benefica Prisma Lima
Trigoso, Dixner Rengifo
Peru, Lima
Asociacion Benefica Prisma Lima
Vasquez, Angel Orbe
Peru, Lima
Asociacion Benefica Prisma Lima
Ahmed, Imran
Pakistan, Karachi
The Aga Khan University
Alam, Didar
Pakistan, Karachi
The Aga Khan University
Ali, Asad S.
Pakistan, Karachi
The Aga Khan University
Bhutta, Zulfiqar A.
Pakistan, Karachi
The Aga Khan University
Qureshi, Shahida Mumtaz
Pakistan, Karachi
The Aga Khan University
Soofi, Sajid Bashir
Pakistan, Karachi
The Aga Khan University
Turab, Ali
Pakistan, Karachi
The Aga Khan University
Zaidi, Anita Kaniz Mehdi
Pakistan, Karachi
The Aga Khan University
Bodhidatta, Ladaporn
Thailand, Bangkok
Armed Forces Research Institute of Medical Sciences, Thailand
Mason, Carl J.
Thailand, Bangkok
Armed Forces Research Institute of Medical Sciences, Thailand
Babji, Sudhir
India, Vellore
Christian Medical College, Vellore
Bose, Anuradha
India, Vellore
Christian Medical College, Vellore
George, Ajila T.
India, Vellore
Christian Medical College, Vellore
Hariraju, Dinesh
India, Vellore
Christian Medical College, Vellore
Jennifer, Mats Steffi
India, Vellore
Christian Medical College, Vellore
John, Sushil Mathew
India, Vellore
Christian Medical College, Vellore
Kaki, Shiny
India, Vellore
Christian Medical College, Vellore
Kang, Gangandeep
India, Vellore
Christian Medical College, Vellore
Karunakaran, Priyadarshani
India, Vellore
Christian Medical College, Vellore
Lazarus, Robin Penugula
India, Vellore
Christian Medical College, Vellore
Muliyil, Jayaprakash
India, Vellore
Christian Medical College, Vellore
Mohan, Venkata Raghava
India, Vellore
Christian Medical College, Vellore
Raju, Sophy
India, Vellore
Christian Medical College, Vellore
Ramachandran, Anup
India, Vellore
Christian Medical College, Vellore
Ramadas, Rakhi
India, Vellore
Christian Medical College, Vellore
Ramanujam, Karthikeyan
India, Vellore
Christian Medical College, Vellore
Bose, Anuradha
India, Vellore
Christian Medical College, Vellore
Sharma, Srujan Lam
India, Vellore
Christian Medical College, Vellore
Shanmuga Sundaram, E.
India, Vellore
Christian Medical College, Vellore
Thomas, Rahul Jacob
India, Vellore
Christian Medical College, Vellore
Pan, William K.Y.
United States, Bethesda
National Institutes of Health Nih
United States, Durham
Duke University
Ambikapathi, Ramya
United States, Bethesda
National Institutes of Health Nih
Daniel Carreon, J.
United States, Bethesda
National Institutes of Health Nih
Charu, Vivek
United States, Bethesda
National Institutes of Health Nih
Doan, Viyada
United States, Bethesda
National Institutes of Health Nih
Graham, Jhanelle
United States, Bethesda
National Institutes of Health Nih
Hoest, Christel
United States, Bethesda
National Institutes of Health Nih
Knobler, Stacey L.
United States, Bethesda
National Institutes of Health Nih
Lang, Dennis R.
United States, Bethesda
National Institutes of Health Nih
McGrath, Monica
United States, Bethesda
National Institutes of Health Nih
Miller, Mark A.
United States, Bethesda
National Institutes of Health Nih
Mohale, Archana
United States, Bethesda
National Institutes of Health Nih
Nayyar, Gaurvika M.L.
United States, Bethesda
National Institutes of Health Nih
Psaki, Stephanie R.
United States, Bethesda
National Institutes of Health Nih
Wang, Vivian Ota
United States, Bethesda
National Institutes of Health Nih
Blank, Rebecca R.
United States, Bethesda
National Institutes of Health Nih
Gottlieb, Michael
United States, Bethesda
National Institutes of Health Nih
Tountas, Karen H.
United States, Bethesda
National Institutes of Health Nih
Amour, Caroline
Tanzania, Mbulu
Haydom Lutheran Hospital
Bayyo, Eliwaza B.
Tanzania, Mbulu
Haydom Lutheran Hospital
Mduma, Estomih R.
Tanzania, Mbulu
Haydom Lutheran Hospital
Mvungi, Regisiana
Tanzania, Mbulu
Haydom Lutheran Hospital
Nshama, Rosemary P.
Tanzania, Mbulu
Haydom Lutheran Hospital
Pascal, John
Tanzania, Mbulu
Haydom Lutheran Hospital
Swema, Buliga Mujaga
Tanzania, Mbulu
Haydom Lutheran Hospital
Yarrot, Ladislaus Blacy
Tanzania, Mbulu
Haydom Lutheran Hospital
Ahmed, Tahmeed
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Shamsir Ahmed, Abul Mansur
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Haque, Rashidul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Hossain, Iqbal
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Islam, Mohammad Munirul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Mahfuz, Mustafa U.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Mondal, Dinesh K.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Tofail, Fahmida
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Chandyo, Ram Krishna
Nepal, Kathmandu
Tribhuvan University
Shrestha, Prakash Sunder
Nepal, Kathmandu
Tribhuvan University
Ulak, Manjeswori
Nepal, Kathmandu
Tribhuvan University
Bauck, Aubrey
United States, Baltimore
Johns Hopkins University
Black, Robert E.
United States, Baltimore
Johns Hopkins University
Checkley, William N.
United States, Bethesda
National Institutes of Health Nih
United States, Baltimore
Johns Hopkins University
Kosek, Margaret N.
United States, Baltimore
Johns Hopkins University
Lee, Gwenyth O.Neill
United States, Baltimore
Johns Hopkins University
Schulze, Kerry J.
United States, Baltimore
Johns Hopkins University
Peñataro Yori, Pablo
United States, Baltimore
Johns Hopkins University
Ross, A. Catharine
United States, University Park
Pennsylvania State University
Schaefer, Barbara A.
United States, Bethesda
National Institutes of Health Nih
United States, University Park
Pennsylvania State University
Simons, Suzanne
United States, University Park
Pennsylvania State University
Abreu, Claúdia B.
Brazil, Fortaleza
Universidade Federal do Ceará
Costa, Hilda
Brazil, Fortaleza
Universidade Federal do Ceará
Moura, Alessandra Di
Brazil, Fortaleza
Universidade Federal do Ceará
Filho, José Quirino S.
United States, Bethesda
National Institutes of Health Nih
Brazil, Fortaleza
Universidade Federal do Ceará
Havt, Alexandre
Brazil, Fortaleza
Universidade Federal do Ceará
Leite, Álvaro Jorge Madeiro
Brazil, Fortaleza
Universidade Federal do Ceará
Moreira Lima, Aldo Ângelo
Brazil, Fortaleza
Universidade Federal do Ceará
Lima, Noélia Leal
Brazil, Fortaleza
Universidade Federal do Ceará
Lima, Ila Fernanda Nunes
Brazil, Fortaleza
Universidade Federal do Ceará
MacIel, Bruna Leal Lima
Brazil, Fortaleza
Universidade Federal do Ceará
Medeiros, Pedro Henrique Quintela Soares
Brazil, Fortaleza
Universidade Federal do Ceará
Moraes, Milena L.
Brazil, Fortaleza
Universidade Federal do Ceará
Mota, Francisco Suetônio Bastos
Brazil, Fortaleza
Universidade Federal do Ceará
Quetz, Josiane S.
Brazil, Fortaleza
Universidade Federal do Ceará
Soares, Alberto Melo
Brazil, Fortaleza
Universidade Federal do Ceará
Mota, Rosa Maria Salani
Brazil, Fortaleza
Universidade Federal do Ceará
Patil, Crystal L.
United States, Chicago
University of Illinois at Chicago
Bessong, Pascal Obong
South Africa, Thohoyandou
University of Venda
Mahopo, Cloupas
South Africa, Thohoyandou
University of Venda
Nyathi, Emanuel
South Africa, Thohoyandou
University of Venda
Samie, Amidou
South Africa, Thohoyandou
University of Venda
Barrett, Leah J.
United States, Charlottesville
University of Virginia
Dillingham, Rebecca Anne
United States, Charlottesville
University of Virginia
Gratz, Jean C.
United States, Charlottesville
University of Virginia
Guerrant, Richard Littleton
United States, Charlottesville
University of Virginia
Houpt, Eric R.
United States, Charlottesville
University of Virginia
Petri, William Arthur J.
United States, Charlottesville
University of Virginia
Platts-Mills, James A.
United States, Charlottesville
University of Virginia
Shrestha, Binob
Unknown Affiliation
Shrestha, Sanjaya Kumar
Unknown Affiliation
Strand, Tor A.
Norway, Bergen
Universitetet I Bergen
Statistics
Citations: 21
Authors: 135
Affiliations: 18
Identifiers
Doi:
10.1542/PEDS.2019-3660
ISSN:
00314005
Research Areas
Food Security
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative