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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort
Journal of Adolescent Health, Volume 49, No. 1, Year 2011
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Description
Purpose Although adolescents are at high risk for human immunodeficiency virus (HIV) infection, they have not been, included in HIV vaccine trials. Methods In preparation for enrollment in HIV vaccine trials, 100 HIV-negative adolescents aged 1417 years from Cape Town were recruited into a cohort. HIV, syphilis, pregnancy testing, and sexual risk questionnaires were conducted at varying intervals for a year. Results The mean age of the participants was 15 years, and 70% of them were female. Recruitment was completed within 3 months. Retention was found to be 82% at 1-year follow-up. The main reasons for dropout were as follows: relocation to other communities, phlebotomy, and visit frequency. In a Cox proportional hazards model, only female gender was significantly associated with retention. No change in reported sexual risk occurred, but the proportion of individuals who were aware of their partner's HIV status was significantly higher (17% at baseline, 83% at 1-year follow-up; p < .001). Five pregnancies were reported during follow-up. Conclusions To our knowledge, this is the first prospective adolescent HIV-prevention cohort in Southern Africa. Despite reports of risky sexual behaviors and high pregnancy rates, HIV seroconversions did not occur in the retained cohort. HIV-prevention trials with high-risk adolescents will require rigorous efforts to prevent future pregnancies, and may require risk eligibility criteria. Retention may improve with transport provision, visits with incentives, and efforts to retain males. © 2011 Society for Adolescent Health and Medicine. All rights reserved.
Authors & Co-Authors
Jaspan, Heather B.
South Africa, Cape Town
University of Cape Town
United States, Seattle
University of Washington
Flisher, Alan J.
South Africa, Cape Town
Adolescent Health Research Institute
Norway, Bergen
Universitetet I Bergen
Myer, Landon
South Africa, Cape Town
University of Cape Town
United States, New York
Mailman School of Public Health
Mathews, Catherine
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Middelkoop, Keren
South Africa, Cape Town
University of Cape Town
Mark, Daniella
South Africa, Cape Town
University of Cape Town
Bekker, Linda-Gail Gail
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 19
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1016/j.jadohealth.2010.10.009
ISSN:
1054139X
e-ISSN:
18791972
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female