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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Children of Senegal River Basin show the highest prevalence of Blastocystis sp. ever observed worldwide
BMC Infectious Diseases, Volume 14, No. 1, Article 164, Year 2014
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Description
Background: Blastocystis sp. is currently the most common intestinal protist found in human feces and considered an emerging parasite with a worldwide distribution. Because of its potential impact in public health, we reinforced the picture of Blastocystis sp. prevalence and molecular subtype distribution in Africa by performing the first survey of this parasite in Senegal.Methods: Stool samples from 93 symptomatic presenting with various gastrointestinal disorders or asymptomatic children living in three villages of the Senegal River Basin were tested for the presence of Blastocystis sp. by non-quantitative and quantitative PCR using primer pairs targeting the SSU rDNA gene. Positive samples were subtyped to investigate the frequency of Blastocystis sp. subtypes in our cohort and the distribution of subtypes in the symptomatic and asymptomatic groups of children.Results: By the use of molecular tools, all 93 samples were found to be positive for Blastocystis sp. indicating a striking parasite prevalence of 100%. Mixed infections by two or three subtypes were identified in eight individuals. Among a total of 103 subtyped isolates, subtype 3 was most abundant (49.5%) followed by subtype 1 (28.2%), subtype 2 (20.4%) and subtype 4 (1.9%). Subtype 3 was dominant in the symptomatic group while subtypes 1 and 2 were detected with equal frequency in both symptomatic and asymptomatic groups. The distribution of subtypes was compared with those available in other African countries and worldwide. Comparison confirmed that subtype 4 is much less frequently detected or absent in Africa while it is commonly found in Europe. Potential sources of Blastocystis sp. infection including human-to-human, zoonotic, and waterborne transmissions were also discussed.Conclusions: The prevalence of Blastocystis sp. in our Senegalese population was the highest prevalence ever recovered worldwide for this parasite by reaching 100%. All cases were caused by subtypes 1, 2, 3 and 4 with a predominance of subtype 3. More than half of the children infected by Blastocystis sp. presented various gastrointestinal disorders. Such high prevalence of blastocystosis in developing countries makes its control a real challenge for public health authorities. © 2014 El Safadi et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3987649/bin/1471-2334-14-164-S1.pdf
Authors & Co-Authors
El Safadi, Dima
France, Lille
Université de Lille
Lebanon, Beirut
Université Libanaise
Gaayeb, Lobna
France, Lille
Université de Lille
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Meloni, Dionigia
France, Lille
Université de Lille
Japan, Tsukuba
Riken Brc Microbe Division Jcm
Cian, Amandine
France, Lille
Université de Lille
Poirier, Philippe
France, Aubiere
Laboratoire Microorganismes : Génome et Environnement
Wawrzyniak, Ivan
France, Aubiere
Laboratoire Microorganismes : Génome et Environnement
Delbac, Frédéric
France, Aubiere
Laboratoire Microorganismes : Génome et Environnement
Dabboussi, Fouad
Lebanon, Beirut
Université Libanaise
Delhaès, Laurence
France, Lille
Université de Lille
Seck, Modou
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Hamzé, Monzer M.
Lebanon, Beirut
Université Libanaise
Riveau, Gilles J.
France, Lille
Université de Lille
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé
Viscogliosi, Éric
France, Lille
Université de Lille
Statistics
Citations: 225
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2334-14-164
e-ISSN:
14712334
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal