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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents
European Journal of Medicinal Chemistry, Volume 62, Year 2013
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Description
Azole class of compounds are well known for their excellent therapeutic properties. Present paper describes about the synthesis of three series of new 1,2,4-triazole and benzoxazole derivatives containing substituted pyrazole moiety (11a-d, 12a-d and 13a-d). The newly synthesized compounds were characterized by spectral studies and also by C, H, N analyses. All the synthesized compounds were screened for their analgesic activity by the tail flick method. The antimicrobial activity of the new derivatives was also performed by Minimum Inhibitory Concentration (MIC) by the serial dilution method. The results revealed that the compound 11c having 2,5-dichlorothiophene substituent on pyrazole moiety and a triazole ring showed significant analgesic and antimicrobial activity. © 2012 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Vijesh, A. M.
India, Visakhapatnam
Gitam University
Isloor, Arun Mohan
India, Mangalore
National Institute of Technology Karnataka
Shetty, Prashanth
India, Mangalore
Ngsm Institute of Pharmaceutical Sciences
Sundershan, S.
India, Bengaluru
University of Agricultural Sciences, Bangalore
Fun, Hoongkun Kaun
Saudi Arabia, Riyadh
College of Pharmacy
Statistics
Citations: 254
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1016/j.ejmech.2012.12.057
ISSN:
02235234
e-ISSN:
17683254