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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment
American Journal of Tropical Medicine and Hygiene, Volume 77, No. 4, Year 2007
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Description
Schistosomiasis mansoni is usually a chronic infection that leads to long-term, systemic exposure to schistosome antigens. Experimental Schistosoma mansoni infection is associated with immunoregulatory mechanisms, including T regulatory cells (Treg) that may help control morbidity and dampen resistance to re-infection. We now show that some schistosomiasis mansoni patients have high proportions of CD3+/CD4+/CD25high Treg. On effective treatment with praziquantel, these high Treg percentages decrease, and fewer of the remaining Treg express CD45RO. The proportion of Treg in S. mansoni-infected patients is inversely related to their percentage of activated, putative effector T cells (CD3+/CD4+/CD25 medium/HLA-DR+ cells). We conclude some, but not all, schistosomiasis mansoni patients develop high percentages of circulating Treg, and effective treatment both decreases the levels of these cells and changes their phenotypes, possibly because of the removal of constant exposure to antigens from intravascular, egg-producing adult worms. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Watanabe, Kanji
Japan, Nagasaki
Nagasaki University
Mwinzi, Pauline Ngina M.
Kenya, Nairobi
Kenya Medical Research Institute
Black, Carla L.
United States, Athens
University of Georgia
Muok, Erick Mbata O.
Kenya, Nairobi
Kenya Medical Research Institute
Karanja, Diana M.Sabwa
Kenya, Nairobi
Kenya Medical Research Institute
Secor, William Evan
United States, Atlanta
Centers for Disease Control and Prevention
Colley, Daniel G.
United States, Athens
University of Georgia
Statistics
Citations: 110
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2007.77.676
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases