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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation
Immunity, Volume 42, No. 2, Year 2015
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Description
Candida albicans is a dimorphic fungus responsible for chronic mucocutaneous and systemic infections.Mucocutaneous immunity to C.albicans requires Thelper 17 (Th17) cell differentiation that is thought to depend on recognition of filamentous C.albicans. Systemic immunity is considered Tcell independent. Using a murine skin infection model, we compared T helper cell responses to yeast and filamentous C.albicans. We found that only yeast induced Th17 cell responses through a mechanism that required Dectin-1-mediated expression of interleukin-6 (IL-6) by Langerhans cells. Filamentous forms induced Th1 without Th17 cell responses due to the absence of Dectin-1 ligation. Notably, Th17 cell responses provided protection against cutaneous infection while Th1 cell responses providedprotection against systemic infection. Thus, C.albicans morphology drives distinct T helper cell responses that provide tissue-specific protection. These findings provide insight into compartmentalization of Th cell responses and C.albicans pathogenesis and have critical implications for vaccine strategies. © 2015 Elsevier Inc.
Authors & Co-Authors
Drummond, Rebecca A.
United Kingdom, Aberdeen
University of Aberdeen
Berman, Judith G.
United States, Minneapolis
University of Minnesota Twin Cities
Israel, Tel Aviv-yafo
Tel Aviv University
Iwasaki, Akiko
United States, New Haven
Yale School of Medicine
Brown, Gordon D.A.
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 161
Authors: 4
Affiliations: 5
Identifiers
Doi:
10.1016/j.immuni.2015.01.008
ISSN:
10747613