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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Schistosomiasis PCR in vaginal lavage as an indicator of genital Schistosoma haematobium infection in rural Zimbabwean women
American Journal of Tropical Medicine and Hygiene, Volume 81, No. 6, Year 2009
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Description
Schistosoma real-time polymerase chain reaction (PCR) is sensitive and specific in urine and stool. We sought to explore the relationship between genital schistosomiasis and the Schistosoma PCR in women. PCR was run on 83 vaginal lavage samples from a rural Zimbabwean population. Women underwent clinical and colposcopic investigations, analyses for sexually transmitted infections, and genital schistosomiasis. Thirty samples were positive for Schistosoma PCR: 12 were strong and 18 were weak positive. Sensitivity (67%) and specificity (83%) were best in women below the age of 25 years. A positive schistosome PCR result was associated with S. haematobium ova in genital tissue, so-called sandy patches, and bleeding. Prevalence determined by PCR were lower and real-time PCR values were weaker in older women. The presence of Schistosoma DNA may be greater in the recent lesions (e.g., in younger women). For diagnosis in rural areas and in large studies, Schistosoma PCR could become a supplement to gynecologic examinations. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Kjetland, Eyrun Floerecke
Norway, Oslo
Oslo Universitetssykehus
Ten Hove, Robert Jan
Netherlands, Leiden
Leids Universitair Medisch Centrum
Gomo, Exnevia
Zimbabwe, Harare
University of Zimbabwe
Midzi, Nicholas
United Kingdom, Birmingham
National Institute for Health Research
Gwanzura, Lovemore K.Z.
Unknown Affiliation
Mason, Peter R.
Unknown Affiliation
Friis, Henrik M.U.
Denmark, Copenhagen
Københavns Universitet
Verweij, Jaco J.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Gundersen, Svein Gunnar
Norway, Kristiansand
Sørlandet Hospital hf
Norway, Kristiansand
Universitetet I Agder
Ndhlovu, Patricia Doris
Zimbabwe, Harare
University of Zimbabwe
Mduluza, Takafira
Zimbabwe, Harare
University of Zimbabwe
van Lieshout, Lisette
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 75
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.2009.09-0081
ISSN:
00029637
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Female