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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ultrastructural and immunogenic changes in the formation of mycetoma grains
Medical Mycology, Volume 25, No. 1, Year 1987
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Description
The differences in the fine structure and antigenic determinants of mycetoma fungi in the mycelial phase in vitro and in grains in vivo facilitate an interpretation of grain formation. Aggreagates of hyphal elements with multiple and thickened walls was a feature of the fungi in vivo. Associated with hyphal wall material, numerous polysaccharide microfibrils were detected in grains of Madurella mycetomatis. These were not seen associated with hyphal elements in vitro and it is suggested that these structures may be concerned with the aggregation of fungal elements in the formation of grains. Antibodies directed against the fungi in vitro were shown, by indirect immunogold labelling, to bind at identical sites in fungal material grown in vitro as in mycetoma grains. However the grain matrix was not labelled, suggesting that part of the structure formed in vivo is composed of modified antigen or is host derived. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Authors & Co-Authors
Wethered, Diana B.
Unknown Affiliation
Markey, M. A.
Unknown Affiliation
Hay, Roderick James
Unknown Affiliation
Mahgoub, Elsheikh
Unknown Affiliation
Gumaa, Samia A.
Unknown Affiliation
Statistics
Citations: 26
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1080/02681218780000051
ISSN:
13693786