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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis
American Journal of Obstetrics and Gynecology, Volume 204, No. 4, Year 2011
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Description
Objective: The objective was to examine the use of a tailor-made DNA microarray containing probes representing the vaginal microbiota to examine bacterial vaginosis. Study Design: One hundred one women attending a health center for HIV testing in South Africa were enrolled. Stained, liquid-based cytology slides were scored for bacterial vaginosis. An inventory of organisms was obtained using microarray technology, probing genera associated with bacterial vaginosis in more detail, namely Gardnerella, Atopobium, Dialister, Leptotrichia, Megasphaera, Mobiluncus, Peptostreptococcus, Prevotella, and Sneathia. Results: Of 101 women, 34 were diagnosed positive for bacterial vaginosis. This condition was associated with an increased microbial diversity. It is no longer useful to base the diagnosis of bacterial vaginosis on Gardnerella alone. Rather, its presence with Leptotrichia and Prevotella species, and especially Atopobium was more indicative of an aberrant state of the vaginal flora. Conclusion: To understand the vaginal microbiota in more detail, microarray-based identification can be used after microscopic scoring. © 2011 Mosby, Inc. All rights reserved.
Authors & Co-Authors
Dols, Joke A.M.
Netherlands, Rotterdam
Erasmus Mc
Smit, Pieter Willem
Netherlands, Leiden
Leiden Cytology and Pathology Laboratory
Kort, Remco
Netherlands, The Hague
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek- Tno
Reid, Gregor
Canada, London
Western University
Schuren, Frank H.J.
Netherlands, The Hague
Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek- Tno
Tempelman, Hugo A.
South Africa
Health Clinic
Bontekoe, Tj Romke
Netherlands, Leiden
Bontekoe Research
Korporaal, Hans
Netherlands, Leiden
Leiden Cytology and Pathology Laboratory
Boon, Mathilde E.
Netherlands, Leiden
Leiden Cytology and Pathology Laboratory
Statistics
Citations: 66
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/j.ajog.2010.11.012
ISSN:
00029378
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
South Africa
Participants Gender
Female