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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: A meta-analysis
Gene, Volume 505, No. 2, Year 2012
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Description
Studies of the relationship between male infertility and polymorphisms in the regions of FSHR G-29A (rs1394205), 919A>G (Thr 307Ala, rs6165) and 2039A>G (Asn 680Ser, rs6166) have reported inconsistent results. To assess the association between them, a meta-analysis was conducted. PubMed and CBMdisc literature search were conducted to identify all eligible studies investigating such a relationship. The pooled ORs were performed for co-dominant model, dominant model and recessive model in FSHR G-29A, Thr 307Ala and Asn 680Ser respectively to assess the strength of association. A total of 1644 male infertility cases and 1748 controls were collected from seven case-control studies. In the overall analysis, no significant association between the three polymorphisms and risk of male infertility was observed. Stratified analysis showed that there were no significantly increased risks of azoospermia and oligoasthenoteratozoospermia (OAT) in any of the genetic models. This meta-analysis supports that FSHR G-29A, Thr 307Ala and Asn 680Ser polymorphisms may not be capable of causing male infertility susceptibility. © 2012 Elsevier B.V.
Authors & Co-Authors
de Moor, Bart L.R.
Belgium, Leuven
Ku Leuven
Marchal, Kathleen
Belgium, Leuven
Ku Leuven
Belgium, Ghent
Universiteit Gent
Wang, Xinru
China, Nanjing
State Key Laboratory of Reproductive Medicine
China, Beijing
Ministry of Education of the People's Republic of China
Statistics
Citations: 23
Authors: 3
Affiliations: 5
Identifiers
Doi:
10.1016/j.gene.2012.02.023
ISSN:
18790038
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Approach
Systematic review
Participants Gender
Male