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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Antimicrobial susceptibility of Streptococcus pneumoniae in adult patients with pneumococcal pneumonia in an urban hospital in Mozambique
BMC Research Notes, Volume 7, No. 1, Article 110, Year 2014
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Description
Background: Streptococcus pneumoniae is the leading cause of community-acquired pneumonia in Africa. Antimicrobial resistance of S. pneumoniae to penicillin and other commonly used antibiotics has increased worldwide. However, prevalence data from the African region are sparse, especially with regard to adults. Findings. In this study, adult patients presenting at an urban referral hospital in central Mozambique were screened for pneumococcal pneumonia during an 8-week period in 2010: Patients with a respiratory syndrome underwent chest radiography and a sputum sample was collected for pneumococcal culture and antimicrobial susceptibility testing. A urine sample was tested for the presence of pneumococcal antigen.177 patients with a respiratory syndrome were included. Overall, 41/177 (23%) patients fulfilled criteria for definite or probable pneumococcal pneumonia and in the group of patients with a positive chest x-ray this concerned 35/86 (41%) patients. 166 sputum cultures yielded 16 pneumococcal strains. One mg oxacillin disc testing identified potential penicillin resistance in 7/16 (44%) strains. Penicillin minimal inhibitory concentrations (MICs) were measured for 15 of these strains and ranged from <0.016-0.75 mg/L. No MICs >2 mg/L were found, but 3/15 (20%) pneumococcal strains had MICs >0.5 mg/L. All pneumococci were sensitive to erythromycin as measured by disc diffusion testing, whereas 44% was resistant to trimethoprim-sulfametoxazole. Conclusions: The proportion of pneumonia cases attributable to pneumococcus appeared to be high. Whilst none of the S. pneumoniae strains tested were penicillin resistant, standard penicillin dosing for pneumonia may be insufficient given the observed range of pneumococcal penicillin MICs. © 2014 Bos et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Bos, Jeannet C.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Amsterdam Institute for Global Health and Development
Beishuizen, Sara J.E.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Madeira, Geoffrey C.
Mozambique, Beira
Universidade Católica de Moçambique
Gomonda, Elmano Dos Santos
Mozambique, Beira
Universidade Católica de Moçambique
Mozambique, Beira
Hospital Central da Beira
Cossa, Esmeralda O.
Mozambique, Beira
Hospital Central da Beira
Macome, Augusto Cesar
Mozambique, Beira
Hospital Central da Beira
van Steenwijk, Reindert P.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Schultsz, Constance
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Amsterdam Institute for Global Health and Development
Prins, Jan M.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Statistics
Citations: 9
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1186/1756-0500-7-110
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Mozambique