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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Celecoxib, a selective cyclooxygenase-2 inhibitor, attenuates renal injury in a rat model of cisplatin-induced nephrotoxicity
Chemotherapy, Volume 57, No. 4, Year 2011
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Description
Background: Cisplatin is an effective chemotherapeutic agent successfully used in the treatment of a wide range of tumors. Nevertheless, nephrotoxicity has restricted its clinical use. Recent studies have strongly suggested that inflammatory mechanisms may play an important role in the pathogenesis of cisplatin nephrotoxicity. Celecoxib, a selective cyclooxygenase-2 inhibitor used as anti-inflammatory, may therefore have a protective effect on cisplatin-induced renal injury. Methods: In the present study, rats were injected intraperitoneally with a single dose of cisplatin (7 mg/kg) and/or celecoxib (30 mg/kg) for 5 days. Results: Nephrotoxicity manifested biochemically by elevations in serum creatinine, blood urea nitrogen, and proteinuria, and an increase in kidney weight as a percentage of total body weight. In addition, a marked decrease in serum albumin was observed. Lipid peroxidation in the kidney was monitored by measuring the malondialdehyde level and glutathione content, which were increased and depleted, respectively. Administration of celecoxib with cisplatin attenuated cisplatin-induced changes in kidney function parameters and oxidative stress markers. Histopathological examination of the kidney confirmed these results. Conclusion: In conclusion, this study indicates that celecoxib may be a promising drug for clinical use as a nephroprotectant against cisplatin-induced nephrotoxicity. Copyright © 2011 S. Karger AG, Basel.
Authors & Co-Authors
Suddek, Ghada M.
Egypt, Mansoura
Mansoura University
El-Kenawi, Asmaa E.
Egypt, Mansoura
Mansoura University
Abdel-Aziz, Azza A.
Egypt, Mansoura
Faculty of Medicine
El-Kashef, Hassan Ahmed
Egypt, Mansoura
Mansoura University
Statistics
Citations: 29
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1159/000329529
ISSN:
00093157
e-ISSN:
14219794
Research Areas
Violence And Injury