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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
STX6 rs1411478 is not associated with increased risk of Parkinson's disease
Parkinsonism and Related Disorders, Volume 19, No. 5, Year 2013
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Description
A variant in Syntaxin 6 (a soluble N-ethylmaleimide-sensitive factor attachment protein receptor STX6) (rs1411478) has been shown to be associated with progressive supranuclear palsy (PSP). Although Parkinson's disease (PD) and PSP are distinct neurodegenerative diseases, they share some clinical and genetic features. In this study, we evaluated STX6 genetic variability in PD susceptibility in ethnically matched case-control series from Canada, Norway, Taiwan and Tunisia and we evaluated the presence of pathogenic mutations within families. No pathogenic mutations were found in STX6. Similarly, statistical analysis of rs1411478 failed to identify differences in genotype or allelic frequencies between cases and controls. Our results do not support a role for STX6 in PD. © 2013 Elsevier Ltd.
Authors & Co-Authors
Trinh, Joanne
Canada, Vancouver
The University of British Columbia
Vilarino-Guell, Carles
Canada, Vancouver
The University of British Columbia
Donald, Alan
Canada, Vancouver
The University of British Columbia
Shah, Brinda
Canada, Vancouver
The University of British Columbia
Yu, Irene S.
Canada, Vancouver
The University of British Columbia
Szu-Tu, Chelsea
Canada, Vancouver
The University of British Columbia
Aasly, Jan Olav
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Wu, Ruey Meei
Taiwan, Taipei
National Taiwan University Hospital
Hentati, F. F.
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Rajput, Ali H.
Canada, Saskatoon
Saskatchewan Health Authority
Rajput, Alex H.
Canada, Saskatoon
Saskatchewan Health Authority
Farrer, Matthew J.
Canada, Vancouver
The University of British Columbia
Statistics
Citations: 16
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1016/j.parkreldis.2013.01.019
e-ISSN:
18735126
Research Areas
Disability
Genetics And Genomics
Study Design
Case-Control Study
Study Approach
Quantitative
Study Locations
Tunisia