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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Collagen genes and exercise-associated muscle cramping
Clinical Journal of Sport Medicine, Volume 23, No. 1, Year 2013
Notification
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Description
OBJECTIVE:: The authors hypothesized that variants within genes, such as COL5A1, COL3A1, COL6A1, and COL12A1, that code for connective tissue components of the musculoskeletal system may modulate susceptibility to exercise-associated muscle cramping (EAMC). Specifically, the aim of this study was to investigate if the COL5A1 rs12722 (C/T), COL3A1 rs1800255 (G/A), COL6A1 rs35796750 (T/C), and COL12A1 rs970547 (A/G) polymorphisms are associated with a history of EAMC. DESIGN:: Retrospective genetic case-control association study. SETTING:: Participants were recruited at triathlon and ultra-marathon events and were asked to report physical activity, medical history, and cramping history. PARTICIPANTS:: One hundred sixteen participants with self-reported history of EAMC within the past 12 months before an ultra-endurance event were included as cases in this study (EAMC group). One hundred fifty participants with no self-reported history of previous (lifelong) EAMC were included as controls (NON group). INTERVENTIONS:: All participants were genotyped for the selected variants. MAIN OUTCOME MEASURES:: Differences in genotype frequency distributions, for COL5A1 rs12722, COL3A1 rs1800255, COL6A1 rs35796750, and COL12A1 rs970547, among the cases and controls. RESULTS:: The COL5A1 CC genotype was significantly overrepresented (P = 0.031) among the NON group (21.8%) when compared with the EAMC group (11.1%). No significant genotype differences were found for the COL3A1 (P = 0.828), COL6A1 (P = 0.300), or COL12A1 (P = 0.120) genotypes between the EAMC and NON groups. CONCLUSIONS:: This study identified, for the first time, the COL5A1 gene as a potential marker for a history of EAMC. © 2013 by Lippincott Williams & Wilkins.
Authors & Co-Authors
O'Connell, Kevin Sean
South Africa, Cape Town
Faculty of Health Sciences
Posthumus, Michael
South Africa, Cape Town
Faculty of Health Sciences
Schwellnus, MP Peter
South Africa, Cape Town
Faculty of Health Sciences
Collins, Malcolm R.
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 28
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1097/JSM.0b013e3182686aa7
ISSN:
1050642X
e-ISSN:
15363724
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Case-Control Study