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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The prevalence of coeliac disease in Libyan children with type 1 diabetes mellitus
Diabetes/Metabolism Research and Reviews, Volume 19, No. 1, Year 2003
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Description
Background. Diagnosis of atypical and silent forms of coeliac disease (CD) is important because of its serious complications. Increased prevalence of coeliac disease worldwide in individuals with type 1 diabetes mellitus (DM) was described. There are no data on the prevalence of CD in the Libyan population and Libyan DM patients. The aim of this study was to test the occurrence of CD-related markers in a group of Libyan children with DM. Methods. A cohort of 234 Libyan children with DM (121 males and 113 females) aged between 2 and 25 years and 50 healthy school children were screened for CD using the enzyme-linked immunosorbent assay (ELISA) for IgA and IgG antigliadin (AGA), anti-tissue transglutaminase (tTG), and anticalreticulin antibodies. An IgA antiendomysial antibody (EmA) was determined by immunofluorescence. Results. Fifty patients (21.3%) were positive for IgA- and/or IgG-AGA, tTG, and anticalreticulin antibodies. Nineteen of these patients were EMA positive and seven were EmA negative. From the EmA negative patients we found that five sera with IgA deficiency had high IgG class in antigliadin, anti-tissue transglutaminase, and anticalreticulin antibodies. All these patients underwent intestinal biopsy. Twenty-four had clear histological (atrophy) evidence of CD including the EmA negative patients with IgA deficiency; prevalence of CD in this study was thus 10.3%. Conclusion. The prevalence of CD in diabetic children in Libya was found to be higher than in several European countries. Serological markers are useful for identifying DM patients who should undergo a small intestinal biopsy. Copyright © 2002 John Wiley & Sons, Ltd.
Authors & Co-Authors
Ashabani, Abdelhakim
Czech Republic, Prague
Institute of Microbiology of the Academy of Sciences of the Czech Republic
Libya, Tripol
Alfatah University
Abushofa, Umaima
Libya, Tripol
Alfatah University
Abusrewill, Suliman
Libya, Tripol
Alfatah University
Abdelazez, Mahmoud
Libya, Tripol
Alfatah University
Tučková, Ludmila
Czech Republic, Prague
Institute of Microbiology of the Academy of Sciences of the Czech Republic
Tlaskalová-Hogenova, Helena
Czech Republic, Prague
Institute of Microbiology of the Academy of Sciences of the Czech Republic
Statistics
Citations: 50
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1002/dmrr.333
ISSN:
15207552
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Libya
Participants Gender
Female