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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic β-cells, skeletal muscle cells, and adipocytes
Pharmaceutical Biology, Volume 46, No. 1-2, Year 2008
Notification
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Description
The seeds of Nigella sativa L. (NS), a plant of the Runanculaceae family, are used in traditional medicine in North Africa and the Middle East for the treatment of diabetes. Despite widespread use and a number of scientific studies, the target tissues and cellular mechanisms of action of this plant product are not well understood. This study evaluated the effects of NS seed crude ethanol extract on insulin secretion in INS832/13 and β TC-tet lines of pancreatic β-cells and on glucose disposal by C2C12 skeletal muscle cells and 3T3-L1 adipocytes. An 18-h treatment with NS amplified glucose-stimulated insulin secretion by more than 35% without affecting sensitivity to glucose. NS treatment also accelerated β-cell proliferation. An 18-h treatment with NS increased basal glucose uptake by 55% (equivalent to approximately two-fold the effect of 100 nM insulin) in muscle cells and approximately by 400% (equal to the effect of 100 nM insulin) in adipocytes; this effect was perfectly additive to that of insulin in adipocytes. Finally, NS treatment of pre-adipocytes undergoing differentiation accelerated triglyceride accumulation comparably with treatment with 10 μM rosiglitazone. It is concluded that the well-documented in vivo antihyperglycemic effects of NS seed extract are attributable to a combination of therapeutically relevant insulinotropic and insulin-like properties. © 2008 Informa Healthcare USA, Inc.
Authors & Co-Authors
Benhaddou-Andaloussi, Ali
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Canada, Montreal
Montreal Diabetes Research Center
Martineau, Louis Charles
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Canada, Montreal
Montreal Diabetes Research Center
Spoor, Danielle C.A.
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Canada, Montreal
Montreal Diabetes Research Center
Vuong, Tri
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Canada, Montreal
Montreal Diabetes Research Center
Leduc, Charles
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Joly, Érik C.
Canada, Montreal
Montreal Diabetes Research Center
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Burt, Andrew James
Canada, Ottawa
University of Ottawa
Meddah, Bouchra
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Settaf, Abdellatif
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Arnason, John Thor A.
Canada, Ottawa
University of Ottawa
Prentki, Marc
Canada, Montreal
Montreal Diabetes Research Center
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Haddad, Pierre Sélim
Canada, Montreal
University of Montreal
Canada, Quebec
Institut Des Nutraceutiques et Des Aliments Fonctionnels, Canada
Canada, Montreal
Montreal Diabetes Research Center
Statistics
Citations: 76
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1080/13880200701734810
ISSN:
13880209
e-ISSN:
17445116
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Locations
Multi-countries