Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts
Kidney International Reports, Volume 8, No. 10, Year 2023
Notification
URL copied to clipboard!
Description
Introduction: Despite recognized geographic and sex-based differences in hemoglobin in the general population, these factors are typically ignored in patients with chronic kidney disease (CKD) in whom a single therapeutic range for hemoglobin is recommended. We sought to compare the distribution of hemoglobin across international nondialysis CKD populations and evaluate predictors of hemoglobin. Methods: In this cross-sectional study, hemoglobin distribution was evaluated in each cohort overall and stratified by sex and estimated glomerular filtration rate (eGFR). Relationships between candidate predictors and hemoglobin were assessed from linear regression models in each cohort. Estimates were subsequently pooled in a random effects model. Results: A total of 58,613 participants from 21 adult cohorts (median eGFR range of 17–49 ml/min) and 3 pediatric cohorts (median eGFR range of 26–45 ml/min) were included with broad geographic representation. Hemoglobin values varied substantially among the cohorts, overall and within eGFR categories, with particularly low mean hemoglobin observed in women from Asian and African cohorts. Across the eGFR range, women had a lower hemoglobin compared to men, even at an eGFR of 15 ml/min (mean difference 5.3 g/l, 95% confidence interval [CI] 3.7–6.9). Lower eGFR, female sex, older age, lower body mass index, and diabetic kidney disease were all independent predictors of a lower hemoglobin value; however, this only explained a minority of variance (R2 7%–44% across cohorts). Conclusion: There are substantial regional differences in hemoglobin distribution among individuals with CKD, and the majority of variance is unexplained by demographics, eGFR, or comorbidities. These findings call for a renewed interest in improving our understanding of hemoglobin determinants in specific CKD populations. © 2023
Authors & Co-Authors
Alencar de Pinho, Natalia
France, Paris
Inserm
Ahn, Yo-han
South Korea, Seoul
Seoul National University College of Medicine
Calice-Silva, Viviane
Brazil, Joinville
Universidade da Regiao de Joinville
Dionne, Janis M.
Canada, Vancouver
The University of British Columbia
Ebert, Natalie
Germany, Berlin
Charité – Universitätsmedizin Berlin
Furth, Susan Lynn
United States, Philadelphia
University of Pennsylvania
Hoy, Wendy E.
United States, Jackson
University of Mississippi Medical Center
Australia, Clayton
Monash University
Australia, Brisbane
The University of Queensland
Jager, Kitty J.
Netherlands, Amsterdam
Amsterdam Public Health
Netherlands, Amsterdam
Universiteit Van Amsterdam
Jha, Vivekanand K.
Australia, Sydney
George Institute for Global Health
United Kingdom, London
Imperial College London
India, Manipal
Manipal Academy of Higher Education
Kang, Hee Gyung
South Korea, Seoul
Seoul National University College of Medicine
Onu, Ugochi Chika
Nigeria, Naukka
University of Nigeria
Pecoits-Filho, Roberto
United States, Ann Arbor
Arbor Research Collaborative for Health
Brazil, Curitiba
Pontifícia Universidade Católica do Paraná
Schaefer, Franz
Germany, Heidelberg
Universitätsklinikum Heidelberg
Schaeffner, Elke S.
Germany, Berlin
Charité – Universitätsmedizin Berlin
Solá, Laura
Unknown Affiliation
Ulasi, Ifeoma I.
Nigeria, Naukka
University of Nigeria
Wang, Jinwei
China, Beijing
Peking University First Hospital
China, Beijing
Peking University
Yadav, Ashok Kumar
India, Chandigarh
Postgraduate Institute of Medical Education & Research, Chandigarh
Taal, Maarten W.
United Kingdom, Nottingham
University of Nottingham Medical School
Stengel, Brian Né Dicte
France, Paris
Inserm
Levin, Adeera I.
Canada, Vancouver
The University of British Columbia
Ahn, Curie
Unknown Affiliation
Caskey, Fergus J.
Unknown Affiliation
Dekker, Friedo W.
Unknown Affiliation
Drechsler, Christiane
Unknown Affiliation
Eckardt, Kai Uwe
Unknown Affiliation
Ferreiro, Alejandro
Unknown Affiliation
Hemmelder, Marc H.H.
Unknown Affiliation
Hilbrands, Luuk B.
Unknown Affiliation
Köttgen, Anna
Unknown Affiliation
Kronenberg, Florian
Unknown Affiliation
Matheson, Matthew B.
Unknown Affiliation
Oefner, Peter J.
Unknown Affiliation
Reis, André
Unknown Affiliation
Rosivall, László
Unknown Affiliation
Sangthawan, Pornpen
Unknown Affiliation
Schmid, Matthias C.
Unknown Affiliation
Shin, Jae-il
Unknown Affiliation
Sommerer, Claudia
Unknown Affiliation
Torino, Claudia
Unknown Affiliation
Verhaar, Marianne C.
Unknown Affiliation
Wanner, Christoph
Unknown Affiliation
Więcek, Andrzej
Unknown Affiliation
Wolf, Günter B.
Unknown Affiliation
Zhang, Luxia
Unknown Affiliation
Statistics
Authors: 45
Affiliations: 32
Identifiers
Doi:
10.1016/j.ekir.2023.07.032
ISSN:
24680249
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female