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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: Results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93
Annals of Oncology, Volume 18, No. 7, Year 2007
Notification
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Description
Background: The International Breast Cancer Study Group (IBCSG) conducted two complementary randomized trials to assess whether a treatment-free gap during adjuvant chemotherapy influenced outcome. Patients and methods: From 1993 to 1999, IBCSG Trials 13-93 and 14-93 enrolled 2215 premenopausal and postmenopausal women with axillary node-positive, operable breast cancer. All patients received cyclophosphamide (Cytoxan, C) plus either doxorubicin (Adriamycin, A) or epirubicin (E) for four courses followed immediately (No Gap) or after a 16-week delay (Gap) by classical cyclophosphamide, methotrexate, and fluorouracil (CMF) for three courses. The median follow-up was 7.7 years. Results: The Gap and No-Gap groups had similar disease-free survival (DFS) and overall survival (OS). No identified subgroup showed a statistically significant difference, but exploratory subgroup analysis noted a trend towards decreased DFS for Gap compared with No Gap for women with estrogen receptor (ER)-negative tumors not receiving tamoxifen, especially evident during the first 2 years. Conclusions: A 16-week gap between adjuvant AC/EC and CMF provided no benefit and may have increased early recurrence rates in patients with ER-negative tumors. © 2007 European Society for Medical Oncology.
Authors & Co-Authors
Colleoni, Marco Angelo
Italy, Milan
Istituto Europeo Di Oncologia
Gelber, Shari I.
United States, Boston
Dana-farber Cancer Institute
Simoncini, Edda Lucia
Italy, Brescia
Spedali Civili Di Brescia
Pagani, O.
Switzerland, Bellinzona
Ospedale San Giovanni
Gelber, Richard D.
Unknown Affiliation
Price, Karen N.
United States, Boston
Dana-farber Cancer Institute
Castiglione-Gertsch, Monica
Switzerland, Bern
Sakk, Switzerland
Coates, Alan S.
Australia, Sydney
Royal Prince Alfred Hospital
Goldhirsch, Aaron
Italy, Milan
Istituto Europeo Di Oncologia
Switzerland, Bellinzona
Ospedale San Giovanni
Thürlimann, Beat J.K.
Switzerland, St Gallen
Kantonsspital St.gallen
Castiglione, Monica M.
Unknown Affiliation
Hiltbrunner, Anita
Unknown Affiliation
Holmberg, Stig B.
Unknown Affiliation
Láng, István
Unknown Affiliation
Lindtner, Jurij
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Rudenstam, Carl Magnus
Unknown Affiliation
Senn, Hansjörg
Switzerland, St Gallen
Kantonsspital St.gallen
Veronesi, Andreas
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Egli, G.
Unknown Affiliation
Rabaglio, Manuela
Unknown Affiliation
Maibach, Rudolf C.
Unknown Affiliation
Gelber, Richard D.
United States, Boston
Dana-farber Cancer Institute
Cole, Bernard F.
United States, Boston
Dana-farber Cancer Institute
Regan, Meredith M.
United States, Boston
Dana-farber Cancer Institute
Zahrieh, David M.
United States, Boston
Dana-farber Cancer Institute
Sun, Zhuoxin
United States, Boston
Dana-farber Cancer Institute
Bernhard, Jürg
Unknown Affiliation
Hürny, Christoph
Unknown Affiliation
Gusterson, Barry A.
Unknown Affiliation
Viale, Giuseppe L.
Italy, Milan
Istituto Europeo Di Oncologia
Blacher, Lynette
Unknown Affiliation
Celano, J.
Unknown Affiliation
Isley, Mary R.
Unknown Affiliation
Hinkle, Rita
Unknown Affiliation
Lippert, Sandra
Unknown Affiliation
Scott, Karolyn
Unknown Affiliation
Crivellari, Diana
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Monfardini, Silvio
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Galligioni, Enzo
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Magri, Marisa Donatella
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Buonadonna, Angela
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Massarut, Samuele
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Rossi, Carlo Remigio
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Candiani, Ezio
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Volpe, Rachele
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Roncadin, Mario
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Arcicasa, Mauro
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Coran, Francesco
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Morassut, Sandro
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Marini, Giovanni
Italy, Brescia
Spedali Civili Di Brescia
Marpicati, Patrizia
Italy, Brescia
Spedali Civili Di Brescia
Braga, Marco
Italy, Brescia
Spedali Civili Di Brescia
Grigolato, Piergiovanni
Italy, Brescia
Spedali Civili Di Brescia
Lucini, Laura
Italy, Brescia
Spedali Civili Di Brescia
Martinelli, Giovanni
Italy, Milan
Istituto Europeo Di Oncologia
Cinieri, Saverio
Italy, Milan
Istituto Europeo Di Oncologia
Peccatori, Fedro Alessandro
Italy, Milan
Istituto Europeo Di Oncologia
Luini, Alberto
Italy, Milan
Istituto Europeo Di Oncologia
Orecchia, Roberto
Italy, Milan
Istituto Europeo Di Oncologia
Renne, Giuseppe
Italy, Milan
Istituto Europeo Di Oncologia
Costa, Alberto F.
Italy, Milan
Istituto Europeo Di Oncologia
Veronesi, Paolo
Italy, Milan
Istituto Europeo Di Oncologia
Sacchini, Virgilio S.
Italy, Milan
Istituto Europeo Di Oncologia
Galimberti, Viviana Enrica
Italy, Milan
Istituto Europeo Di Oncologia
Foladore, Silvia
Unknown Affiliation
Foghin, Liliana
Unknown Affiliation
Pamich, G.
Unknown Affiliation
Bianchi, Claudio
Unknown Affiliation
Marino, B.
Unknown Affiliation
Murgia, Alma
Unknown Affiliation
Milan, Vittorino
Unknown Affiliation
Wallgren, Arne S.
Unknown Affiliation
Hultborn, Ragnar
Unknown Affiliation
Cahlin, Erling
Unknown Affiliation
Mattsson, Jan E.
Unknown Affiliation
Ruusvik, O.
Unknown Affiliation
Niklasson, L. G.
Unknown Affiliation
Dahlin, S.
Unknown Affiliation
Bergegårdh, S.
Unknown Affiliation
Salander, Håkan
Unknown Affiliation
Andersson, Christina Allansdotter
Unknown Affiliation
Persson, Stellan
Unknown Affiliation
Suurküla, Mart
Unknown Affiliation
Eržen, Darja
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Čufer, Tanja
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Červek, Jožica
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Cerar, O.
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Golouh, Rastko
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Lamovec, Janez
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Jančar, Janez
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Murray, Elizabeth M.
South Africa, Observatory
Groote Schuur Hospital
Werner, I. Dudley
South Africa, Observatory
Groote Schuur Hospital
Dent, David M.
South Africa, Observatory
Groote Schuur Hospital
Gudgeon, Anne
South Africa, Observatory
Groote Schuur Hospital
Panieri, Eugenio
South Africa, Observatory
Groote Schuur Hospital
McEvoy, Elene
South Africa, Observatory
Groote Schuur Hospital
Toop, J.
South Africa, Observatory
Groote Schuur Hospital
Vorobiof, Daniel Alberto
South Africa, Johannesburg
Sandton Oncology Center
Chasen, Martin Robert
South Africa, Johannesburg
Sandton Oncology Center
Fotheringham, G.
South Africa, Johannesburg
Sandton Oncology Center
de Muelenaere, G.
South Africa, Johannesburg
Sandton Oncology Center
Skudowitz, Ben
South Africa, Johannesburg
Sandton Oncology Center
Mohammed, C.
South Africa, Johannesburg
Sandton Oncology Center
Rosengarten, A.
South Africa, Johannesburg
Sandton Oncology Center
Cortés-Funés, Hernán
Spain, Madrid
Madrid Breast Cancer Group
Mendiola, Caesar
Spain, Madrid
Madrid Breast Cancer Group
Grávalos, Cristina
Spain, Madrid
Madrid Breast Cancer Group
Fey, Martin F.
Switzerland, Bern
Sakk, Switzerland
Schneider, Henning P.G.
Switzerland, Bern
Sakk, Switzerland
Aebi, Stefan
Switzerland, Bern
Sakk, Switzerland
Öhlschlegel, Christian
Switzerland, St Gallen
Kantonsspital St.gallen
Cavalli, Franco
Switzerland, Bellinzona
Ospedale San Giovanni
Rey, Piercarlo
Switzerland, Bellinzona
Ospedale San Giovanni
Bernier, Jacques
Switzerland, Bellinzona
Ospedale San Giovanni
Torhorst, Joachim K.H.
Switzerland, Basel
Universitätsspital Basel
Pestalozzi, Bernhard Cornelius
Switzerland, Olten
Kantonsspital Olten
Perey, Lucien
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Leyvraz, Serge
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Mirimanoff, Renè Olivier
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Bonnefoi, Hervé R.
Unknown Affiliation
Aapro, Matti S.
Unknown Affiliation
Schindler, Adolf Eduard
Unknown Affiliation
Borisch, Bettina
Unknown Affiliation
Wernli, Martin
Switzerland, Aarau
Kantonsspital Aarau
Bargetzi, Mario J.
Switzerland, Aarau
Kantonsspital Aarau
Mingrone, Walter
Switzerland, Aarau
Kantonsspital Aarau
Forbes, John F.
Australia, Waratah
Newcastle Mater Misericordiae Hospital
Simes, Robert John
Australia, Sydney
The University of Sydney
Australia, Sydney
Royal Prince Alfred Hospital
Dhillon, Haryana M.
Australia, Sydney
The University of Sydney
Collins, John Paxton
Australia, East Melbourne
Cancer Council Victoria
Snyder, Raymond D.
Australia, East Melbourne
Cancer Council Victoria
Abdi, Ehtesham A.
Australia, East Melbourne
Cancer Council Victoria
Chirgwin, Jacquie H.
Australia, East Melbourne
Cancer Council Victoria
Ganju, Vinod
Australia, East Melbourne
Cancer Council Victoria
Lindeman, Geoffrey J.
Australia, East Melbourne
Cancer Council Victoria
Team, Suubi+Adherence Field
Australia, East Melbourne
Cancer Council Victoria
Richardson, Gary Edward
Australia, East Melbourne
Cancer Council Victoria
Stuart-Harris, Robin C.
Australia, Canberra
Canberra Hospital
Stewart, Josephine F.
Australia, Waratah
Newcastle Mater Misericordiae Hospital
van Hazel, Guy Arthur
Australia, Perth
Mount Hospital
Australia, Perth
Sir Charles Gairdner Hospital
Friedlander, M. L.
Australia, Sydney
Prince of Wales Hospital
Chan, Arlene
Australia, Perth
Royal Perth Hospital
Byrne, Michael J.J.
Australia, Perth
Sir Charles Gairdner Hospital
Beith, Jane Mc Neil
Australia, Sydney
Royal Prince Alfred Hospital
Tattersall, Martin H.N.
Australia, Sydney
Royal Prince Alfred Hospital
Harvey, Vernon J.
New Zealand, Auckland
Auckland City Hospital
Statistics
Citations: 10
Authors: 146
Affiliations: 29
Identifiers
Doi:
10.1093/annonc/mdm091
ISSN:
09237534
Research Areas
Cancer
Study Design
Cohort Study
Exploratory Study
Participants Gender
Female