Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Meta-analysis of the impact of successful chronic total occlusion percutaneous coronary intervention on left ventricular systolic function and reverse remodeling
Journal of Interventional Cardiology, Volume 31, No. 5, Year 2018
Notification
URL copied to clipboard!
Description
Background: We sought to examine the impact of coronary chronic total occlusion (CTO) percutaneous coronary intervention (PCI) on left ventricular (LV) function. Methods: We performed a systematic review and meta-analysis of studies published between January 1980 and November 2017 on the impact of successful CTO PCI on LV function. Results: A total of 34 observational studies including 2735 patients were included in the meta-analysis. Over a weighted mean follow-up of 7.9 months, successful CTO PCI was associated with an increase in LV ejection fraction by 3.8% (95%CI 3.0-4.7, P < 0.0001, I2 = 45%). In secondary analysis of 15 studies (1248 patients) that defined CTOs as occlusions of at least 3-month duration and reported follow-up of at least 3-months after the procedure, successful CTO PCI was associated with improvement in LV ejection fraction by 4.3% (95%CI [3.1, 5.6], P < 0.0001). In the 10 studies (502 patients) that reported LV end-systolic volume, successful CTO PCI was associated with a decrease in LV end-systolic volume by 4 mL, (95%CI −6.0 to −2.1, P < 0.0001, I2 = 0%). LV end-diastolic volume was reported in 9 studies with 403 patients and did not significantly change after successful CTO PCI (−2.3 mL, 95%CI −5.7 to 1.2 mL, P = 0.19, I2 = 0%). Conclusions: Successful CTO PCI is associated with a statistically significant improvement in LV ejection fraction and decrease in LV end-systolic volume, that may reflect a beneficial effect of CTO recanalization on LV remodeling. The clinical implications of these findings warrant further investigation. © 2018 Wiley Periodicals, Inc.
Authors & Co-Authors
Megaly, Michael S.
United States, Minneapolis
Abbott Northwestern Hospital
United States, Minneapolis
Hennepin County Medical Center
Saad, Marwan
United States, Little Rock
University of Arkansas at Little Rock
Tajti, Péter
United States, Minneapolis
Abbott Northwestern Hospital
Burke, Martin Nicholas
United States, Minneapolis
Abbott Northwestern Hospital
Gössl, Mario
United States, Minneapolis
Abbott Northwestern Hospital
Sorajja, Paul
United States, Minneapolis
Abbott Northwestern Hospital
Kohl, Louis P.
United States, Minneapolis
Hennepin County Medical Center
Brilakis, Emmanouil S.
United States, Minneapolis
Abbott Northwestern Hospital
Statistics
Citations: 44
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1111/joic.12538
ISSN:
08964327
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Systematic review