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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer: Reduction in local treatment failure
European Journal of Cancer, Volume 30, No. 11, Year 1994
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Description
A prospective randomised multicentre trial compared pre-operative radiotherapy followed by surgery with surgery alone for rectal cancer ≤12 cm from the anal verge. Of 468 patients (mean age 67 years, range 31-94, 273 males) who met the entry criteria, 228 were randomised to radiotherapy (3 × 5 Gy over 5 days within 2 days of operation) followed by surgery, and 239 to surgery alone. Randomisation was unknown in 1 patient. Follow-up to death or 5 years was achieved in 454 (97%) patients. 31 (7%) of the 468 patients died within 30 days of operation (radiotherapy and surgery 21 [9%], surgery alone 10 [4%]; P < 0.05). Cardiovascular and thromboembolic complications were more common after radiotherapy and surgery (30, 13%) than after surgery alone (8, 3%; P < 0.005). Of the 280 patients who had curative surgery, 52% of those who had radiotherapy and surgery and 56% of those who had surgery alone survived 5 years (P = 0.88). 395 patients attended outpatients clinics at least once. Local treatment failure was identified during follow-up in 82 patients [ 31 185 (17%) radiotherapy and surgery; 51 210(24%) surgery alone; P < 0.05]. It occurred in 33 of the 258 patients who had a curative resection and attended outpatients [radiotherapy and surgery, 11 120(9%), surgery alone, 22 138(16%), P = 0.08]. Long-term survival was unaffected, but long-term local recurrence was reduced by the addition of low-dose radiotherapy to surgery. Peri-operative mortality was, however, increased. © 1994.
Authors & Co-Authors
Goldberg, Paul A.
United Kingdom, Harrow
St Mark’s Hospital
United Kingdom, London
Cancer Research uk
Love, Sharon B.
United Kingdom, Harrow
St Mark’s Hospital
United Kingdom, London
Cancer Research uk
Statistics
Citations: 262
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/0959-8049(94)00312-S
ISSN:
09598049
Research Areas
Cancer
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study