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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 1
7
glucocorticoid receptor promoter region
Metabolic Brain Disease, Volume 24, No. 4, Year 2009
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Description
Separating rat pups from their mothers during the early stages of life is an animal model commonly used to study the development of psychiatric disorders such as anxiety and depression. The present study investigated how soon after the termination of the maternal separation period behavioural and neuroendocrine abnormalities relevant to above-mentioned illnesses would manifest. Sprague Dawley rat pups were subjected to maternal separation (3 h per day from postnatal day 2 through 14) and their behaviour and HPA axis activity determined 7 d later. We also measured nerve growth factor levels in their hippocampi and assessed the DNA methylation status of the promoter region of exon 17 of the glucocorticoid receptor in this brain region. As early as 7 d after the termination of the adverse event, a change in behaviour was observed that was associated with increased plasma corticosterone release and elevated nerve growth factor levels in the hippocampus. No alteration in the methylation status of the exon 17 glucocorticoid receptor promoter region was observed. Our data indicate that early life adversity may lead to the rapid development of abnormal behaviours and HPA axis dysregulation though no epigenetic changes to the exon 17 glucocorticoid receptor promoter region occurred. We further propose that the observed increased neurotrophin levels reflect compensatory mechanisms that attempt to combat the long-term deleterious effects of maternal separation. © 2009 Springer Science+Business Media, LLC.
Authors & Co-Authors
Daniels, Willie Mark Uren
South Africa, Congella
University of Kwazulu-natal, Faculty of Health Sciences
Fairbairn, Lorren
South Africa, Stellenbosch
Stellenbosch University
Van Tilburg, G.
South Africa, Stellenbosch
Stellenbosch University
McEvoy, Christopher R.E.
South Africa, Stellenbosch
Stellenbosch University
Zigmond, Michael J.
United States, Pittsburgh
University of Pittsburgh School of Medicine
Russell, Vivienne Ann
South Africa, Cape Town
University of Cape Town
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 118
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1007/s11011-009-9163-4
Research Areas
Genetics And Genomics
Maternal And Child Health
Mental Health