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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina
International Journal of Biological Sciences, Volume 5, No. 4, Year 2009
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Description
Spirulina platensis (SP) is a filamentous cyanobacterium microalgae with potent dietary phyto-antioxidant, anti-inflammatory and anti-cancerous properties. The present study aimed to investigate the chemopreventive effect of SP against rat liver toxicity and carcinogenesis induced by dibutyl nitrosamine (DBN) precursors, and further characterized its underlying mechanisms of action in HepG2 cell line. Investigation by light and electron microscopy showed that DBN treatment induced severe liver injury and histopathological abnormalities, which were prevented by SP supplementation. The incidence of liver tumors was significantly reduced from 80 to 20% by SP. Immunohistochemical results indicated that both PCNA and p53 were highly expressed in the liver of DBN-treated rats, but were significantly reduced by SP supplementation. Molecular analysis indicated that SP treatment inhibited cell proliferation, which was accompanied by increased p21 and decreased Rb expression levels at 48hrs post-treatment. In addition, SP increased Bax and decreased Bcl-2 expression, indicating induction of apoptosis by 48hrs. This is the first report of the in vivo chemopreventive effect of SP against DBN-induced rat liver cytotoxicity and carcinogenesis, suggesting its potential use in chemoprevention of cancer. © Ivyspring International Publisher.
Authors & Co-Authors
Ismail, Mohamed F.
Egypt, Mansoura
Faculty of Science
Ali, Doaa A.
Egypt, Mansoura
Faculty of Science
Fernando, Augusta
United States, New Orleans
Lsuhsc School of Medicine
Abdraboh, Mohamed Elsaid
United States, New Orleans
Lsuhsc School of Medicine
Gaur, Rajiv L.
United States, New Orleans
Lsuhsc School of Medicine
Ibrahim, Wael M.
Egypt, Mansoura
Faculty of Science
Raj, Madhwa H.G.
United States, New Orleans
Lsuhsc School of Medicine
Ouhtit, Allal
United States, New Orleans
Lsuhsc School of Medicine
Egypt, Mansoura
Faculty of Science
Statistics
Citations: 112
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.7150/ijbs.5.377
ISSN:
14492288
Research Areas
Cancer
Violence And Injury
Study Design
Cohort Study