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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Neurofilament light increases over time in severe COVID-19 and is associated with delirium
Brain Communications, Volume 4, No. 4, Article fcac195, Year 2022
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Description
Neurological monitoring in sedated Intensive Care Unit patients is constrained by the lack of reliable blood-based biomarkers. Neurofilament light is a cross-disease biomarker for neuronal damage with potential clinical applicability for monitoring Intensive Care Unit patients. We studied the trajectory of neurofilament light over a month in Intensive Care Unit patients diagnosed with severe COVID-19 and explored its relation to clinical outcomes and pathophysiological predictors. Data were collected over a month in 31 Intensive Care Unit patients (166 plasma samples) diagnosed with severe COVID-19 at Amsterdam University Medical Centre, and in the first week after emergency department admission in 297 patients with COVID-19 (635 plasma samples) admitted to Massachusetts General hospital. We observed that Neurofilament light increased in a non-linear fashion in the first month of Intensive Care Unit admission and increases faster in the first week of Intensive Care Unit admission when compared with mild-moderate COVID-19 cases. We observed that baseline Neurofilament light did not predict mortality when corrected for age and renal function. Peak neurofilament light levels were associated with a longer duration of delirium after extubation in Intensive Care Unit patients. Disease severity, as measured by the sequential organ failure score, was associated to higher neurofilament light values, and tumour necrosis factor alpha levels at baseline were associated with higher levels of neurofilament light at baseline and a faster increase during admission. These data illustrate the dynamics of Neurofilament light in a critical care setting and show associations to delirium, disease severity and markers for inflammation. Our study contributes to determine the clinical utility and interpretation of neurofilament light levels in Intensive Care Unit patients. © 2022 The Author(s).
Authors & Co-Authors
Smeele, Patrick J.
Netherlands, Amsterdam
Amsterdam Neuroscience
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Duitman, Jan Willem
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Nossent, Esther J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Heunks, Leo M.A.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Horn, Janneke
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Bogaard, H. J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Van Agtmael, Michiel A.
Unknown Affiliation
van Baarle, Frank E.F.P.
Unknown Affiliation
Bonta, Peter I.
Unknown Affiliation
Bos, Lieuwe D.J.
Unknown Affiliation
de Brabander, Justin
Unknown Affiliation
de Bree, Godelieve J.
Unknown Affiliation
de Bruin, Sanne
Unknown Affiliation
Bugiani, Marianna
Unknown Affiliation
Chekrouni, Nora
Unknown Affiliation
Duijvelaar, Erik
Unknown Affiliation
Elbers, Paul W.G.
Unknown Affiliation
Geerlings, Suzanne Eugenie
Unknown Affiliation
Goorhuis, Bram
Unknown Affiliation
Grobusch, Martín Peter
Unknown Affiliation
Hagens, Laura A.
Unknown Affiliation
Harris, Vanessa C.
Unknown Affiliation
Hermans, S. M.
Unknown Affiliation
Hollmann, Markus Wiersma
Unknown Affiliation
Hovius, Joppe Willem R.
Unknown Affiliation
de Jong, Menno Douwe
Unknown Affiliation
Koning, Rutger
Unknown Affiliation
Lim, Endry H.T.
Unknown Affiliation
Olie, Sabine E.
Unknown Affiliation
Peters, Edgar J.
Unknown Affiliation
van der Poll, Tom
Unknown Affiliation
Schippers, Job R.
Unknown Affiliation
Schultz, Marcus Josephus
Unknown Affiliation
Sigaloff, Kim Catherina Eve
Unknown Affiliation
Slim, Marleen A.
Unknown Affiliation
Smit, Marry R.
Unknown Affiliation
Tuinman, Pieter Roel
Unknown Affiliation
van der Valk, Marc
Unknown Affiliation
Veelo, Denise Petra
Unknown Affiliation
van Vugt, Michèle V.
Unknown Affiliation
Zwinderman, Aeilko Having Koos
Unknown Affiliation
Brouwer, Matthijs C.
Unknown Affiliation
Wiersinga, Willem Joost
Unknown Affiliation
Vlaar, Alexander Petrus Johannes
Unknown Affiliation
van de Beek, Diederik V.D.
Unknown Affiliation
Team, Suubi+Adherence Field
Netherlands, Amsterdam
Amsterdam Neuroscience
Statistics
Citations: 5
Authors: 46
Affiliations: 2
Identifiers
Doi:
10.1093/braincomms/fcac195
ISSN:
26321297
Research Areas
Cancer
Covid
Health System And Policy