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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Natural killer cells are recruited during pulmonary tuberculosis and their ex vivo responses to mycobacteria vary between healthy human donors in association with KIR haplotype
Cellular Microbiology, Volume 14, No. 11, Year 2012
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Description
Humans vary widely in their susceptibility to tuberculosis. While only a minority will progress to disease, the majority of healthy individuals exposed to Mycobacterium tuberculosis mount an immune response that can clear or contain the infection in a quiescent form. Using immunofluorescence on human clinical samples, we identified natural killer (NK) cells infiltrating granulomatous pulmonary lesions during active disease. In order to compare the NK cell ability to react to free mycobacteria in the context of tuberculosis infection and Mycobacterium bovis BCG vaccination, NK cells were isolated from the peripheral blood of anonymous healthy human donors, and stimulated with M.tuberculosis H37Rv or M.bovis BCG. Extracellular M.tuberculosis and M.bovis BCG could equally trigger the release of IFNγ and TNFα from NK cells in the presence of IL-2. However, we found that this response varied 1000-fold between individuals (n=52), with differences in KIR haplotype providing a significant criterion to distinguish between low and high responders. Our findings suggest that variations at the KIR locus and therefore of the NK cell repertoire may affect cytokine production in response to mycobacteria and we propose that this innate variability couldsustain different levels of susceptibility to M.tuberculosis infection. © 2012 Blackwell Publishing Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3503254/bin/cmi0014-1734-SD1.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3503254/bin/cmi0014-1734-SD2.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3503254/bin/cmi0014-1734-SD3.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3503254/bin/cmi0014-1734-SD4.tif
Authors & Co-Authors
Portevin, Damien
United Kingdom, London
Mrc National Institute for Medical Research
Via, L. E.
United States, Bethesda
National Institutes of Health Nih
Eum, Seokyong
South Korea, Changwon
International Tuberculosis Research Center
Young, Douglas Brownlee
United Kingdom, London
Mrc National Institute for Medical Research
Statistics
Citations: 63
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1111/j.1462-5822.2012.01834.x
ISSN:
14625822
Research Areas
Genetics And Genomics