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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Risk of HIV-1 transmission by breastfeeding among mothers infected with recombinant and non-recombinant HIV-1 genotypes
Virus Research, Volume 120, No. 1-2, Year 2006
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Description
Background: Viral genotype and intersubtype recombination may influence the rate and/or timing of mother-to-child HIV-1 transmission. Methods: We determined the HIV-1 subtype of the C2-C5 env and 5′LTR regions from milk and blood samples of 61 Tanzanian mothers who transmitted the virus through breastfeeding and their HIV-1 positive non-transmitting controls. Cases and controls were matched on infant's age at sample collection. All mothers resided in Dar es Salaam, Tanzania. Results: Most infections among cases were due to recombinant viruses (41.0%), followed by HIV-1 subtype A (26.2%), subtype D (19.7%), and subtype C (13.1%). In multivariate analysis including maternal CD4+ cell counts, HIV disease stage, and proviral load in breast milk, the odds of breast milk transmission were 7.2 times higher if the mother carried an intersubtype recombinant genome in comparison to a subtype C virus (p = 0.02). Viruses with recombinant LTRs were 4.9 times more likely to be transmitted through breastfeeding than viruses with non-recombinant LTRs of subtype A, C or D combined (p = 0.01). Conclusions: This suggested that intersubtype recombinant genomes, and especially recombination within the LTR, might render HIV-1 more fit for transmission via breast milk in comparison with non-recombinant subtypes A, C, and D. © 2006 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Koulinska, Irene N.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Villamor, Eduardo
United States, Boston
Harvard T.h. Chan School of Public Health
Msamanga, Gernard I.
Tanzania, Dar es Salaam
Muhimbili Medical Centre
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Blackard, Jason Tory
United States, Cincinnati
University of Cincinnati College of Medicine
Renjifo, Boris R.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Essex, Max E.
United States, Boston
Harvard T.h. Chan School of Public Health Aids Initiative
Statistics
Citations: 38
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.virusres.2006.03.007
ISSN:
01681702
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Locations
Tanzania