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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Nature Communications, Volume 9, No. 1, Article 4616, Year 2018
Notification
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Description
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10−15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification. © 2018, The Author(s).
Authors & Co-Authors
Matejcic, Marco
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Saunders, Edward J.
United Kingdom, London
The Institute of Cancer Research
Dadaev, Tokhir
United Kingdom, London
The Institute of Cancer Research
Brook, Mark N.
United Kingdom, London
The Institute of Cancer Research
Sheng, Xin
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Al Olama, Ali Amin
United Kingdom, Cambridge
University of Cambridge
Schumacher, Fredrick R.
United States, Cleveland
Case Western Reserve University
United States, Cleveland
University Hospitals Case Medical Center
Ingles, Sue Ann
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Govindasami, Koveela
United Kingdom, London
The Institute of Cancer Research
Benlloch, Sara
United Kingdom, London
The Institute of Cancer Research
United Kingdom, Cambridge
University of Cambridge
Berndt, Sonja I.
United States, Bethesda
National Institutes of Health Nih
Albanes, Demetrius
United States, Bethesda
National Institutes of Health Nih
Koutros, Stella
United States, Bethesda
National Institutes of Health Nih
Muir, Kenneth Ross
United Kingdom, Manchester
The University of Manchester
United Kingdom, Coventry
University of Warwick
Stevens, Victoria L.
United States, Kennesaw
American Cancer Society
Gapstur, Susan M.
United States, Kennesaw
American Cancer Society
Tangen, Catherine M.
United States, Seattle
Fred Hutchinson Cancer Center
Batra, Jyotsna
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Clements, Judith Ann
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Grönberg, Henrik
Sweden, Stockholm
Karolinska Institutet
Pashayan, Nora
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Schleutker, Johanna
Finland, Turku
Turun Yliopisto
Finland, Turku
Turun Yliopistollinen Keskussairaala
Finland, Tampere
Biomeditech Finland
Wolk, Alicja
Sweden, Stockholm
Karolinska Institutet
West, Catharine Mary Louise
United Kingdom, Manchester
Health Innovation Manchester
Mucci, Lorelei Ann
United States, Boston
Harvard T.h. Chan School of Public Health
Kraft, Peter
United States, Boston
Harvard T.h. Chan School of Public Health
Cancel-Tassin, Géraldine
France, Paris
Hôpital Tenon
Sørensen, Karina Dalsgaard Dalsgaard
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Aarhus
Aarhus Universitet
Grindedal, Eli Marie
Norway, Oslo
Oslo Universitetssykehus
Strom, Sara S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Neal, David E.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Cancer Research uk Cambridge Institute
Hamdy, Freddie Charles
United Kingdom, Oxford
University of Oxford
Donovan, Jenny L.
United Kingdom, Bristol
University of Bristol
Travis, Ruth C.
United Kingdom, Oxford
University of Oxford
Hamilton, Robert James
Canada, Toronto
Princess Margaret Cancer Centre
Rosenstein, Barry S.
United States, New York
Icahn School of Medicine at Mount Sinai
Lu, Yongjie
United Kingdom, London
Queen Mary University of London
Giles, Graham G.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Kibel, Adam S.
United States, Boston
Brigham and Women's Hospital
Vega, Ana Karina
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Bensen, Jeannette T.
United States, Raleigh
The University of North Carolina System
Kogevinas, Manolis
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Institut Municipal D'investigacio Medica
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Penney, Kathryn L.
United States, Boston
Harvard Medical School
Park, Jong-yun
United States, Tampa
Moffitt Cancer Center
Stanford, Janet L.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Cybulski, Cezary
Poland, Szczecin
Pomeranian Medical University in Szczecin
Nordestgaard, BØrge Grønne
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Brenner, Hermann
Germany, Heidelberg
German Cancer Research Center
Maier, Christiane
Germany, Ulm
Universitätsklinikum Ulm
Teixeira, Manuel Rodrigues
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Portugal, Porto
Universidade do Porto
Floris, Giuseppe L.
United States, Duarte
City of Hope National Med Center
de Ruyck, Kim
Belgium, Ghent
Universiteit Gent
Razack, Azad Hassan Abdul
Malaysia, Kuala Lumpur
Universiti Malaya
Newcomb, Lisa F.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Lessel, Davor
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Kaneva, Radka
Bulgaria, Sofia
Medical University of Sofia
Usmani, Nawaid H.
Canada, Edmonton
Cross Cancer Institute
Claessens, Frank
Belgium, Leuven
Ku Leuven
Townsend, Paul A.
United Kingdom, Manchester
Health Innovation Manchester
Gago-Dominguez, Manuela
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
United States, La Jolla
University of California, San Diego
Roobol, Monique J.
Netherlands, Rotterdam
Erasmus Mc
Ménégaux, Florence
France, Paris
Inserm
Khaw, Kay Tee T.
United Kingdom, Cambridge
University of Cambridge
Cannon-Albright, Lisa Anne
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
Pandha, Hardev S.
United Kingdom, Guildford
University of Surrey
Thibodeau, Stephen N.
United States, Rochester
Mayo Clinic
Schaid, Daniel J.
United States, Rochester
Mayo Clinic
Henderson, Brian E.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Stern, Mariana Carla
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Guy, Michelle
United Kingdom, London
The Institute of Cancer Research
Fisher, Cyril J.
United Kingdom, London
The Institute of Cancer Research
Cook, Margaret R.
United Kingdom, Cambridge
University of Cambridge
Fachal, Laura
United Kingdom, Cambridge
University of Cambridge
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Weinstein, Stephanie J.
United States, Bethesda
National Institutes of Health Nih
Beane-Freeman, Laura E.
United States, Bethesda
National Institutes of Health Nih
Hoover, Robert N.
United States, Bethesda
National Institutes of Health Nih
MacHiela, Mitchell J.
United States, Bethesda
National Institutes of Health Nih
Lophatananon, Artitaya
United Kingdom, Manchester
The University of Manchester
United Kingdom, Coventry
University of Warwick
Carter, Brian D.
United States, Kennesaw
American Cancer Society
Goodman, Phyllis J.
United States, Seattle
Fred Hutchinson Cancer Center
Moya, Leire
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Kedda, Mary Anne
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Eklund, Martin
Sweden, Stockholm
Karolinska Institutet
Dunning, Alison M.
United Kingdom, Cambridge
University of Cambridge
Sipeky, Csilla
Finland, Turku
Turun Yliopisto
Håkansson, Niclas N.
Sweden, Stockholm
Karolinska Institutet
Elliott, Rebecca M.
United Kingdom, Manchester
Health Innovation Manchester
Giovannucci, Edward Luciano
United States, Boston
Harvard T.h. Chan School of Public Health
Turman, Constance
United States, Boston
Harvard T.h. Chan School of Public Health
Hunter, D. J.
United States, Boston
Harvard T.h. Chan School of Public Health
Cussenot, Olivier
France, Paris
Hôpital Tenon
Lewis, Sarah J.
United Kingdom, Bristol
University of Bristol
Key, Timothy J.
United Kingdom, Oxford
University of Oxford
Kulkarni, Girish S.
Canada, Toronto
Princess Margaret Cancer Centre
Zlotta, Alexandre R.
Canada, Toronto
Princess Margaret Cancer Centre
Fleshner, Neil Eric
Canada, Toronto
Princess Margaret Cancer Centre
Finelli, Antonio
Canada, Toronto
Princess Margaret Cancer Centre
Marzec, Jacek
United Kingdom, London
Queen Mary University of London
MacInnis, Robert Jeffrey
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Milne, Roger L.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Hopper, John Llewelyn
Australia, Melbourne
University of Melbourne
Bustamante, Mariona
Spain, Barcelona
Instituto de Salud Global de Barcelona
Castaño-Vinyals, Gemma
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Institut Municipal D'investigacio Medica
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Stampfer, Meir J.
United States, Boston
Harvard Medical School
Ma, Jing
United States, Boston
Harvard Medical School
Sellers, Thomas
United States, Tampa
Moffitt Cancer Center
Geybels, Milan S.
United States, Tampa
Moffitt Cancer Center
Kolb, Suzanne
United States, Seattle
Fred Hutchinson Cancer Center
Wokołorczyk, Dominika
Poland, Szczecin
Pomeranian Medical University in Szczecin
Kluzńiak, Wojciech
Poland, Szczecin
Pomeranian Medical University in Szczecin
Nielsen, Sune Fallgaard
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Vogel, Walther
Germany, Ulm
Universitätsklinikum Ulm
Luedeke, Manuel
Germany, Ulm
Universitätsklinikum Ulm
Logothetis, Christopher J.
United States, Houston
The University of Texas Md Anderson Cancer Center
Paulo, Paula
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Maia, Sofia F.
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Steele, Linda
United States, Duarte
City of Hope National Med Center
Ding, Yuanchun
United States, Duarte
City of Hope National Med Center
de Langhe, Sofie
Belgium, Ghent
Universiteit Gent
Thierens, Hubert M.A.
Belgium, Ghent
Universiteit Gent
Ong, Teng Aik
Malaysia, Kuala Lumpur
Universiti Malaya
Lin, Daniel Wei
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Mitev, Vanio Ivanov
Bulgaria, Sofia
Medical University of Sofia
Parliament, Matthew B.
Canada, Edmonton
Cross Cancer Institute
Truong, Thérèse
France, Paris
Inserm
Michael, Agnieszka
United Kingdom, Guildford
University of Surrey
Kierzek, Andrzej M.
United Kingdom, Guildford
University of Surrey
Wu, Huihai
United Kingdom, Guildford
University of Surrey
McDonnell, Shannon K.
United States, Rochester
Mayo Clinic
Spurdle, Amanda B.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Hayes, Vanessa M.
Australia, Sydney
The Kinghorn Cancer Centre
Bentzen, Søren M.
United States, Baltimore
University of Maryland School of Medicine
Hicks, Belynda D.
United States, Reston
Leidos Inc.
Vogt, Aurélie
United States, Reston
Leidos Inc.
Hutchinson, Amy A.
United States, Reston
Leidos Inc.
Cox, Angela
United Kingdom, Sheffield
The University of Sheffield
Evans, Andrew John
Canada, Toronto
University Health Network University of Toronto
van der Kwast, Theodorus H.
Canada, Toronto
University Health Network University of Toronto
Saito, Shiro
Japan, Tokyo
National Hospital Organization Tokyo Medical Center
Yu, Yongwei
China, Shanghai
Second Military Medical University
Pedersen, John Stuart
Australia, Mount Waverley
Tissupath Pty Ltd.
Herkommer, Kathleen
Germany, Munich
Technische Universität München
Carracedo, Ángel M.
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Saudi Arabia, Jeddah
King Abdulaziz University
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Trétarre, Brigitte
Unknown Affiliation
Martin, Richard Michael
United Kingdom, Bristol
University of Bristol
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Royston
National Institute for Health and Care Research
Thompson, Ian Murchie
United States, San Antonio
University of Texas Health Science Center at San Antonio
Chambers, Suzanne K.
Australia, Brisbane
Griffith University
Australia, Spring Hill
The Cancer Council Queensland
Aitken, Joanne F.
Australia, Brisbane
Griffith University
Australia, Spring Hill
The Cancer Council Queensland
Horvath, Lisa G.
Australia, Sydney
Garvan Institute of Medical Research
Haynes, Anne Maree
Australia, Sydney
The Kinghorn Cancer Centre
Australia, Sydney
Garvan Institute of Medical Research
Tilley, Wayne D.
Unknown Affiliation
Risbridger, Gail Petuna
Australia, Clayton
Monash University
Australia, Melbourne
Peter Maccallum Cancer Centre
Aly, Markus
Sweden, Stockholm
Karolinska Institutet
Nordström, Tobias
Sweden, Stockholm
Karolinska Institutet
Pharoah, Paul D.P.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Hinxton
Wellcome Sanger Institute
Tammela, Teuvo L.J.
Finland, Tampere
Tampere University
Auvinen, Anssi Pekka
Finland, Tampere
Tampere University
Burnet, Neil Gunn
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Andriole, Gerald L.
United States, St. Louis
Washington University School of Medicine in St. Louis
Drake, Bettina Fisher
United States, St. Louis
Washington University School of Medicine in St. Louis
Borre, Michael
Denmark, Aarhus
Aarhus Universitet
Denmark, Aarhus
Aarhus Universitetshospital
Ostrer, Harry
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Cao, Guangwen
China, Shanghai
Second Military Medical University
Southey, Melissa Caroline
Australia, Clayton
Monash Health
FitzGerald, Liesel M.
Australia, Melbourne
University of Melbourne
Australia, Hobart
University of Tasmania
Szulkin, Robert
Sweden, Stockholm
Karolinska Institutet
Llorca-Díaz, Javier Francisco
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Santander
Universidad de Cantabria
Dierssen-Sotos, Trinidad
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Santander
Universidad de Cantabria
Gómez-Acebo, Inés
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Santander
Universidad de Cantabria
Lin, Huiyi
United States, New Orleans
Lsu Health Sciences Center - new Orleans
Ostrander, Elaine A.
United States, Bethesda
National Institutes of Health Nih
Klarskov, Peter
Denmark, Copenhagen
Copenhagen University Hospital
Røder, Andreas
Denmark, Copenhagen
Copenhagen University Hospital
Iversen, Peter
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Holleczek, Bernd
Germany, Saarbrucken
Saarland Cancer Registry
Stegmaier, Christa
Germany, Saarbrucken
Saarland Cancer Registry
John, Esther M.
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford University School of Medicine
Ost, Piet
Belgium, Ghent
Universitair Ziekenhuis Gent
Teo, Soo Hwang
Unknown Affiliation
Gamulin, Marija
Croatia, Zagreb
Kbc Zagreb
Popov, Elenko P.
Bulgaria, Sofia
Medical University of Sofia
Joniau, Steven G.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Castelao, Jose Esteban
Spain, Vigo
Complejo Hospitalario Universitario de Vigo
Martínez, María Elena Peña
United States, La Jolla
Moores Cancer Center
Van Schaik, Ron Hn
Netherlands, Rotterdam
Erasmus Mc
Xu, Jienfiang Feng
United States, Evanston
Northshore University Healthsystem
Lindstrom̈, Sara
United States, Seattle
University of Washington
Riboli, Elio B.
United Kingdom, London
Imperial College London
Siddiq, Afshan
United Kingdom, London
Genomics England Limited
Canzian, Federico
Germany, Heidelberg
German Cancer Research Center
Kolonel, Laurence N.
United States, Honolulu
University of Hawaiʻi Cancer Center
Le Marchand, Loic̈
United States, Honolulu
University of Hawaiʻi Cancer Center
Freedman, Matthew Lee
United States, Boston
Dana-farber Cancer Institute
Sanchez, Marie
France, Paris
Inserm
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Wiklund, Fredrik E.
Sweden, Stockholm
Karolinska Institutet
Chanock, Stephen J.
United States, Bethesda
National Institutes of Health Nih
d'Adamo, Adamo P.
United Kingdom, Cambridge
University of Cambridge
Eeles, Rosalind A.
United Kingdom, London
The Institute of Cancer Research
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Kóte-Jarai, Zsofia S.
United Kingdom, London
The Institute of Cancer Research
Conti, David V.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Haiman, Christopher A.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Statistics
Citations: 33
Authors: 201
Affiliations: 134
Identifiers
Doi:
10.1038/s41467-018-06863-1
ISSN:
20411723
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Participants Gender
Male