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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide-induced oxidative stress in rat liver
Ecotoxicology and Environmental Safety, Volume 73, No. 5, Year 2010
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Description
Lipopolysaccharide (LPS) is a glycolipid component of the cell wall of gram-negative bacteria inducing deleterious effects on several organs including the liver and eventually leading to septic shock and death. Endotoxemia-induced hepatotoxicity is characterized by disturbed intracellular redox balance, excessive reactive oxygen species (ROS) accumulation inducing DNA, proteins and membrane lipid damages. Resveratrol (trans-3,5,4' trihydroxystilbene) is a phytoalexin polyphenol exhibiting antioxidant and anti-inflammatory properties. In this study, we investigated the effect of subacute pre-treatment with this natural compound on LPS-induced hepatotoxicity in rat. Resveratrol counteracted LPS-induced lipoperoxidation and depletion of antioxidant enzyme activities as superoxide dismutase (SOD) and catalase (CAT) but slightly glutathione peroxidase (GPx) activity. The polyphenol also abrogated LPS-induced liver and plasma nitric oxide (NO) elevation and attenuated endotoxemia-induced hepatic tissue injury. Importantly resveratrol treatment abolished LPS-induced iron sequestration from plasma to liver compartment. Our data suggest that resveratrol is capable of alleviating LPS-induced hepatotoxicity and that its mode of action may involve differential iron compartmentalization via iron shuttling proteins. © 2010 Elsevier Inc.
Authors & Co-Authors
Sebaí, Hichem
Tunisia, Tunis
University of Carthage
Portugal, Beja
Institut Supérieur de Biotechnologie de Béja
Sani, Mamane
Tunisia, Tunis
University of Carthage
Yacoubi, Mohamed Tahar
Tunisia, Sousse
Hopital Farhat Hached Sousse
Aouani, Ezzedine
Tunisia, Hamam Lif
Centre de Biotechnologie de Borj Cédria
Ghanem-Boughanmi, Néziha
Tunisia, Hamam Lif
Centre de Biotechnologie de Borj Cédria
Ben Attia, M.
Tunisia, Tunis
University of Carthage
Statistics
Citations: 77
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.ecoenv.2009.12.031
ISSN:
01476513
e-ISSN:
10902414
Research Areas
Genetics And Genomics
Violence And Injury