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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Change in IgG and evolution of lung function in children with cystic fibrosis
Journal of Cystic Fibrosis, Volume 10, No. 2, Year 2011
Notification
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Description
Reports from the seventies and eighties have shown that cystic fibrosis (CF) patients with severe lung disease have high levels of IgG and that this is associated with worse prognosis. We decided to explore IgG level as a possible outcome parameter for lung disease severity in a cohort of pediatric CF patients treated according to current standards of care. Seventy three CF children older than 5. years (and max 15. years old at the initial evaluation) attending the same CF center were followed during a period of 4. years. Data collection included spirometry, height, weight, sputum cultures and total IgG. Median age at the start was 10years. IgG z scores<2 SD were seen in 2.7% of patients in 2004 and 2008. Twelve patients (16%) had an IgG>2 SD in 2004 and this number increased to 18 (25%) in 2008. IgG z-scores were inversely correlated with FEV1% predicted (r=-0.323 in 2004; p<.001). In longitudinal evaluation, changes in IgG z-score correlate inversely with changes in FEV1% predicted (r=-0.498; p<.001). We can conclude that even for CF patients treated according to current standards IgG z-score increases with age and is correlated with a decline in FEV1. © 2011 European Cystic Fibrosis Society.
Authors & Co-Authors
Proesmans, Marijke Johanna
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Els, Carla
South Africa, Pretoria
University of Pretoria
Vermeulen, François L.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
de Boeck, Kristiane
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Statistics
Citations: 35
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.jcf.2010.12.004
ISSN:
15691993
Research Areas
Maternal And Child Health
Study Design
Cohort Study
Grounded Theory