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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Anopheles moucheti and Anopheles vinckei Are Candidate Vectors of Ape Plasmodium Parasites, Including Plasmodium praefalciparum in Gabon
PLoS ONE, Volume 8, No. 2, Article e57294, Year 2013
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Description
During the last four years, knowledge about the diversity of Plasmodium species in African great apes has considerably increased. Several new species were described in chimpanzees and gorillas, and some species that were previously considered as strictly of human interest were found to be infecting African apes. The description in gorillas of P. praefalciparum, the closest relative of P. falciparum which is the main malignant agent of human malaria, definitively changed the way we understand the evolution and origin of P. falciparum. This parasite is now considered to have appeared recently, following a cross-species transfer from gorillas to humans. However, the Plasmodium vector mosquito species that have served as bridge between these two host species remain unknown. In order to identify the vectors that ensure ape Plasmodium transmission and evaluate the risk of transfer of these parasites to humans, we carried out a field study in Gabon to capture Anopheles in areas where wild and semi-wild ape populations live. We collected 1070 Anopheles females belonging to 15 species, among which An. carnevalei, An. moucheti and An. marshallii were the most common species. Using mtDNA-based PCR tools, we discovered that An. moucheti, a major human malaria vector in Central Africa, could also ensure the natural transmission of P. praefalciparum among great apes. We also showed that, together with An. vinckei, An. moucheti was infected with P. vivax-like parasites. An. moucheti constitutes, therefore, a major candidate for the transfer of Plasmodium parasites from apes to humans. © 2013 Paupy et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3577705/bin/pone.0057294.s001.doc
Authors & Co-Authors
Paupy, Christophe
France, Paris
Cnrs Centre National de la Recherche Scientifique
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Makanga, Boris Kevin
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Gabon, Libreville
Institut de Recherche en Ecologie Tropicale
Ollomo, Benjamin
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Rahola, Nil
France, Paris
Cnrs Centre National de la Recherche Scientifique
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Durand, Patrick
France, Paris
Cnrs Centre National de la Recherche Scientifique
Magnus, Julie
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Willaume, Eric
Unknown Affiliation
Renaud, François N.R.
France, Paris
Cnrs Centre National de la Recherche Scientifique
Fontenille, Didier
France, Paris
Cnrs Centre National de la Recherche Scientifique
Prugnolle, Franck
France, Paris
Cnrs Centre National de la Recherche Scientifique
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Statistics
Citations: 42
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0057294
e-ISSN:
19326203
Research Areas
Cancer
Infectious Diseases
Study Locations
Gabon
Participants Gender
Female