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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa
Journal of Clinical Microbiology, Volume 50, No. 3, Year 2012
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Description
Genotyping of multidrug-resistant (MDR) Mycobacterium tuberculosis strains isolated from tuberculosis (TB) patients in four South African provinces (Western Cape, Eastern Cape, KwaZulu-Natal, and Gauteng) revealed a distinct population structure of the MDR strains in all four regions, despite the evidence of substantial human migration between these settings. In all analyzed provinces, a negative correlation between strain diversity and an increasing level of drug resistance (from MDR-TB to extensively drug-resistant TB [XDR-TB]) was observed. Strains predominating in XDR-TB in the Western and Eastern Cape and KwaZulu-Natal Provinces were strongly associated with harboring an inhA promoter mutation, potentially suggesting a role of these mutations in XDR-TB development in South Africa. Approximately 50% of XDR-TB cases detected in the Western Cape were due to strains probably originating from the Eastern Cape. This situation may illustrate how failure of efficient health care delivery in one setting can burden health clinics in other areas. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Chihota, Violet N.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
South Africa, Johannesburg
The Aurum Institute
Müller, Borna
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Mlambo, Charmaine Khudzie
South Africa, Johannesburg
University of the Witwatersrand
Pillay, Manormoney
South Africa, Durban
University of Kwazulu-natal
Tait, Marisa
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Streicher, Elizabeth Maria
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Marais, Elsé
South Africa, Johannesburg
University of the Witwatersrand
Van Der Spuy, Gian D.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Hanekom, Madeleine
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Coetzee, Gerrit J.
South Africa, Johannesburg
National Institute for Communicable Diseases
Trollip, André Phillip
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Hayes, Cindy
South Africa, Johannesburg
National Health Laboratory Service
Bosman, Marleine E.
South Africa, Johannesburg
National Health Laboratory Service
Gey van Pittius, Nicolaas Claudius
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Victor, Thomas Calldo
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Van Helden, Paul D.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Warren, Robin Mark
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Statistics
Citations: 64
Authors: 17
Affiliations: 6
Identifiers
Doi:
10.1128/JCM.05832-11
ISSN:
00951137
e-ISSN:
1098660X
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
South Africa