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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence of plasmid-mediated quinolone resistance determinants in Enterobacteriaceae from Tunisia
Clinical Microbiology and Infection, Volume 16, No. 7, Year 2010
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Description
The spread of plasmid-mediated quinolone resistance determinants (qnr-like determinants, aac(6')-Ib-cr and qepA genes) was evaluated in a collection of 281 nalidixic acid-resistant enterobacterial isolates recovered between September 2005 and December 2007 at the Sahloul Hospital, Sousse, Tunisia. Sixteen percent of those isolates carried qnr genes encoding the QnrB1, QnrB2, QnrA6 or QnrS1 determinants. Most qnr-positive isolates were extended-spectrum ß-lactamase (ESBL) producers, being predominantly of the CTX-M-15 type, but also of the SHV-28 and SHV-12 types. The qnr genes were located on plasmids with a size in the range 55-150 kb. The qnrB2 gene was associated with sul1-type integron structures and the qnrB1 gene was associated with orf1005, whereas the genetic environment of qnrA6 was unknown. In two isolates, the qnrS1 gene was located downstream of an ISEcl2 element on plasmids that often carried the narrow-spectrum ß-lactamase gene blaLAP-2; qepA and aac(6')-Ib-cr were not detected. The present study highlights the wide spread of Qnr-like determinants in Tunisia, with an association with the ESBL CTX-M-15 in human clinical isolates. © 2009 The Authors. Journal Compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Dahmen, Safia
France, Le Kremlin-bicetre
Résistances Émergentes Aux Antibiotiques
Tunisia, Sousse
Chu Sahloul
Poirel, Laurent
France, Le Kremlin-bicetre
Résistances Émergentes Aux Antibiotiques
Mansour, Wejdène
Tunisia, Sousse
Chu Sahloul
Bouallègue, Olfa
Tunisia, Sousse
Chu Sahloul
Nordmann, Patrice L.
France, Le Kremlin-bicetre
Résistances Émergentes Aux Antibiotiques
Statistics
Citations: 56
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1469-0691.2009.03010.x
ISSN:
1198743X
e-ISSN:
14690691
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Tunisia