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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Affinity-Purified Respiratory Syncytial Virus Antibodies from Intravenous Immunoglobulin Exert Potent Antibody-Dependent Cellular Cytotoxicity
PLoS ONE, Volume 8, No. 7, Article e69390, Year 2013
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Description
Mixed infections are one of the major therapeutic challenges, as the current strategies have had limited success. One of the most common and widespread conditions of mixed infection is respiratory syncytial virus-mediated pathology of the respiratory tract in children. There is a dire need for the development of novel therapeutic approaches during mixed infections. Therapeutic intravenous immunoglobulin preparations, obtained from plasma pools of healthy donors have been used in immune deficiencies. This study was thus designed to characterize the functional efficacy of RSV-specific antibodies in IVIg. To explore the functional ability of these affinity-purified RSV-specific antibodies, the antibody-dependent and complement dependent cytotoxicity was determined using peripheral cells of healthy donors. This study demonstrates the existence of highly potent RSV-specific antibodies in IVIg preparations and provides the basis for the use of IVIg as broad-spectrum protective shield to RSV-infected children during mixed infections. © 2013 Gupta et al.
Authors & Co-Authors
Gupta, Nimesh
France, Paris
Inserm
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Sorbonne Université
Le-Goff, Jérôme
France, Paris
Université Paris Cité
France, Paris
Hôpital Saint-louis
Chamat, Soulaïma S.
Lebanon, Beirut
Université Libanaise
Mercier-Delarue, Séverine
France, Paris
Hôpital Saint-louis
Touzelet, Olivier
United Kingdom, Belfast
School of Medicine, Dentistry and Biomedical Sciences
Power, Ultan F.
United Kingdom, Belfast
School of Medicine, Dentistry and Biomedical Sciences
Kazatchkine, Michel Daniel
Switzerland, Geneva
Unaids
Simon, Franćois
France, Paris
Université Paris Cité
France, Paris
Hôpital Saint-louis
Lacroix-Desmazes, Sebastien
France, Paris
Inserm
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Sorbonne Université
India, New Delhi
Indian Council of Medical Research
Bayry, Jagadeesh
France, Paris
Inserm
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Sorbonne Université
India, New Delhi
Indian Council of Medical Research
Kaveri, Srini V.
France, Paris
Inserm
France, Paris
Centre de Recherche Des Cordeliers
France, Paris
Sorbonne Université
India, New Delhi
Indian Council of Medical Research
Statistics
Citations: 17
Authors: 11
Affiliations: 9
Identifiers
Doi:
10.1371/journal.pone.0069390
e-ISSN:
19326203
Research Areas
Maternal And Child Health