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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Kaposi sarcoma-associated herpesvirus in non-Hodgkin lymphoma and reactive lymphadenopathy in Uganda
Human Pathology, Volume 38, No. 2, Year 2007
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Description
Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lymphomas (NHLs) and reactive lymphadenopathy in this region. One hundred forty-four cases (80 NHLs, 64 reactive lymph nodes) from the major pathology laboratory in Uganda were reviewed. One NHL was KSHV-positive, as indicated by staining for the viral latent nuclear antigen. This NHL was a diffuse large B-cell lymphoma in a 5-year-old boy. The tumor was also Epstein-Barr virus-positive. In addition, 2 reactive lymph nodes, both classified histologically as follicular involution, stained KSHV latent nuclear antigen-positive and thus most likely represent multicentric Castleman disease. In all 3 KSHV-positive cases, a minority of cells expressed KSHV viral interleukin 6, a biologically active cytokine homolog. In conclusion, we show that KSHV is rarely associated with lymphoproliferative disorders in sub-Saharan Africa. We describe the first case of a KSHV-positive NHL from this region; this case is also the first reported pediatric lymphoma associated with KSHV infection. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Engels, Eric A.
United States, Rockville
National Cancer Institute Nci
Mbulaiteye, Sam M.
United States, Rockville
National Cancer Institute Nci
Othieno, Emmanuel
Uganda, Kampala
Makerere University
Gomez, Mario
Uganda, Kampala
Makerere University
Mathew, Susan
United States, New York
Weill Cornell Medicine
Cesarman, Ethel
United States, New York
Weill Cornell Medicine
Knowles, Daniel M.
United States, New York
Weill Cornell Medicine
Chadburn, Amy
United States, New York
Weill Cornell Medicine
Statistics
Citations: 17
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.humpath.2006.08.009
ISSN:
00468177
Research Areas
Cancer
Study Locations
Uganda
Participants Gender
Male