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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Role of CYP1A2 polymorphisms in breast cancer risk in women
Molecular Medicine Reports, Volume 7, No. 1, Year 2013
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Description
Cytochrome P4501A2 (CYP1A2) is a key enzyme in the etiology of breast cancer (BC). It is involved in breast carcinogen activation [aromatic (AAs) and heterocyclic amines (HAs), polycyclic aromatic hydrocarbons (PAHs)], in the production of beneficial oestrogen [2-hydroxyestrone (2-OHE1)] and in converting arachidonic acid (AAc) to epoxyeicosatrienoic acids (EETs), which have anti-inflammatory properties. Within a hospital-based case-control study, the effect of functional CYP1A2 variants [-3860G/A (rs2069514), -2467T/delT (rs3569413), -163C/A (rs762551)] and their interactions with environmental factors in BC risk was investigated. The study population included 125 BC cases and 43 non-cancer controls. Genotyping was performed in RT-PCR using Taqman assays. The gene-environment interaction was appraised using a case-only study design. We found that the -3860A variant, independently from environmental factors, as well as by interacting with fried foods (p=0.025) and indoor exposure to pollutants (p=0.050), reduced the risk of BC (p=0.025), whereas its interaction with coffee (p=0.045) increased the BC risk. This is the first study indicating that the -3860A variant, by decreasing CYP1A2 activity, modifies BC risk by interacting with environmental factors, thereby supporting the hypothesis that reduced CYP1A2 activity contributes to BC risk in different ways, for example, it may be protective by reducing the activation of pro-carcinogens such as AAs, HAs and PAHs, but would increase risk by reducing the beneficial formation of 2-OHE1 and EETs. © 2013 Spandidos Publications Ltd.
Authors & Co-Authors
Ayari, Imene
Tunisia, Sousse
Université de Sousse
Fedeli, U.
Italy, Padua
Veneto Regional Authority
Saguem, Saâd
Tunisia, Sousse
Université de Sousse
Hidar, Samir
Tunisia, Sousse
Hopital Farhat Hached Sousse
Khlifi, Saida
Tunisia, Sousse
Université de Sousse
Pavanello, Sofia
Italy, Padua
Università Degli Studi Di Padova
Statistics
Citations: 29
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.3892/mmr.2012.1164
ISSN:
17912997
e-ISSN:
17913004
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Female