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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Transmitted antiretroviral drug resistance among newly HIV-1 diagnosed young individuals in Kampala
AIDS, Volume 25, No. 7, Year 2011
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Description
Objective: To assess the emergence of transmitted HIV-1 drug resistance (TDR) in Kampala, Uganda, 10 years after the scale-up of antiretroviral treatment (ART) and to compare with a previous survey among antenatal clinic attendees in 2007 (reporting 0% TDR). Design: A cross-sectional survey was conducted among newly HIV-1 diagnosed, antiretroviral-naive young adults attending two large voluntary counseling and testing centers within the geographic area of Kampala. Methods: Proxy criteria for recent HIV-1 infection were used as defined by the WHO. Population sequencing of the pol gene was performed on plasma samples with HIV-1 RNA at least 1000 copies/ml. Surveillance drug resistance mutations (SDRMs) were identified according to the 2009 WHO list for surveillance of TDR. HIV-1 subtypes were designated using maximum likelihood phylogenetic reconstruction. Results: Genotypic test results were obtained for 70 of 77 (90.9%) participants. SDRMs were identified in six samples yielding a prevalence of TDR of 8.6% (95% confidence interval 3.2-17.7%). Two had SDRMs to nucleoside reverse-transcriptase inhibitors (D67G and L210W), three had SDRMs to nonnucleoside reverse transcriptase inhibitors (G190A, G190S, and K101E), and one had SDRMs to protease inhibitors (N88D). Frequencies of HIV-1 subtypes were A (36/70, 51.4%), C (two of 70; 2.9%), D (23/70, 32.9%), and unique recombinant forms (nine of 70, 12.9%). Conclusion: This repeated survey suggests an increase in TDR in Kampala, compared with a previous survey. This finding justifies increased vigilance with respect to surveillance of TDR in areas in Africa where ART programs are rolled-out. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Ndembi, Nicaise N.
Uganda, Entebbe
Mrc/uvri
United States, Baltimore
University of Maryland School of Medicine
Hamers, Raph L.
Netherlands, Amsterdam
Pharmaccess Foundation
Netherlands, Amsterdam
Universiteit Van Amsterdam
Sigaloff, Kim Catherina Eve
Netherlands, Amsterdam
Pharmaccess Foundation
Netherlands, Amsterdam
Universiteit Van Amsterdam
Lyagoba, Fred F.
Uganda, Entebbe
Mrc/uvri
Magambo, Brian
Uganda, Entebbe
Mrc/uvri
Nanteza, Bridget B.
Uganda, Entebbe
Mrc/uvri
Watera, Christine
Uganda, Entebbe
Mrc/uvri
Kaleebu, Pontiano P.
Uganda, Entebbe
Mrc/uvri
Rinke de Wit, Tobias Floris
Netherlands, Amsterdam
Pharmaccess Foundation
Netherlands, Amsterdam
Universiteit Van Amsterdam
Statistics
Citations: 71
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1097/QAD.0b013e328346260f
e-ISSN:
14735571
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Uganda