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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
In vitro anti-Helicobacter pylori activity of extracts of selected medicinal plants from North West Cameroon
Journal of Ethnopharmacology, Volume 114, No. 3, Year 2007
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Description
Ethnopharmacological relevance: Helicobacter pylori, a gram negative microaerophilic bacterium is a major etiological agent in duodenal, peptic and gastric ulcers. The growing problem of antibiotic resistance by the organism demands the search for novel compounds from plant based sources. Aim of Study: The present study is aimed at evaluating the antimicrobial activity of some selected medicinal plants on clinical isolates of H. pylori circulating in Cameroon in a bid to identify potential sources of cheap starting materials for the synthesis of new drugs. Materials and Methods: Gastric biopsy samples were obtained from patients presenting with gastroduodenal complications. H. pylori was isolated from the specimens following standard microbiology procedures. The disk diffusion method was used to determine the susceptibility of 15 isolates to ten methanol plant extracts (Ageratum conyzoides, Scleria striatinux, Lycopodium cernua, Acanthus montanus, Eryngium foetidium, Aulutandria kamerunensis, Tapeinachilus ananassae, Euphorbia hirta, Emilia coccinea and Scleria verrucosa). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for the most active plant extracts were also determined by the agar dilution method. Results were analyzed statistically by the Fisher's exact test. Results: All the plants tested demonstrated antimicrobial activity with zone diameters of inhibition ranging from 0-30 mm. Of these, A. conyzoides, S. striatinux and L. cernua showed very potent antibacterial activity on the isolates. The lowest MIC and MBC recorded were 0.032 mg/mL and 0.098 mg/mL respectively. However, the MIC of the extracts ranged from 0.032-1.0 mg/mL for S. striatinux; 0.063-0.5mg/mL for L. cernua and 0.063-1.0 mg/mL for A. conyzoides. The MBC of the extracts ranged from 0.098-15.0 mg/mL for S. striatinux; 0.098-12.5 mg/mL for A. conyzoides, and 0.195-12.5 mg/mL for L. cernua. The extracts had a wide spectrum of activity. The three most potent extracts possessed significant (P < 0.05) inhibitory activities. Conclusion: The plant extracts may contain compounds with therapeutic activity. © 2007 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Ndip, Roland
Cameroon, Buea
University of Buea
Malange Tarkang, Alertia E.
Cameroon, Buea
University of Buea
Mbullah, S. M.
Cameroon, Buea
University of Buea
Luma, Henry Namme
Cameroon, Douala
Douala General Hospital
Malongue, Agnès
Cameroon, Douala
Douala General Hospital
Ndip, Lucy Mande
Cameroon, Buea
University of Buea
Nyongbela, Kennedy Dohjinga
Cameroon, Buea
University of Buea
Wirmum, Claire
Unknown Affiliation
Efange, Simon Mbua Ngale
Cameroon, Buea
University of Buea
Statistics
Citations: 147
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1016/j.jep.2007.08.037
ISSN:
03788741
Study Locations
Cameroon