Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer
Human Molecular Genetics, Volume 15, No. 1, Year 2006
Notification
URL copied to clipboard!
Description
Experimental and observational studies in humans and animals suggest that insulin-like growth factor 1 (IGF1) and its principal binding protein, IGFBP3, may influence breast cancer susceptibility. We have examined the association of nine and four single nucleotide polymorphisms (SNPs) in the IGF1 gene and in the IGFBP3 genes, respectively, with circulating levels of their gene products in a population-based study of 600 middle-aged men and women, and in a breast cancer case-control study, comprised 4647 cases and 4564 controls. All study participants are from the East Anglian region of UK. SNPs were specifically chosen to tag all other known SNPs in each gene. Several SNPs in each gene are associated both with circulating levels of their respective proteins and with risk of breast cancer. In particular, the c allele of IGF1 SNPrs1520220 is associated with increased circulating IGF1 (r2 = 2.1%, P-trend = 0.003) in females and an increased risk of breast cancer: odds ratio (OR) (cc/gg) = 1.41; 95% confidence intervals (95% CI) 1.11-1.79, P-trend = 0.03. The a allele of IGFBP3 SNP rs2854744 is associated with increased circulating IGFBP3 (r2 = 9.7%, P<10-9) and a decreased risk of breast cancer: OR (aa/cc) = 0.87; 95% CI 0.77-0.99, P = 0.03. Our data indicate that common variants in the IGF1 and IGFBP3 genes are associated with differences in circulating levels of IGF1 and IGFBP3 and with breast cancer risk. More specifically and consistent with experimental models, our data suggest that higher IGF1 levels may increase the risk of breast cancer but higher IGFBP3 levels may be protective. © The Author 2005. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Al-Zahrani, Ali Saeed
United Kingdom, Cambridge
Strangeways Research Laboratory
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Sandhu, Manjinder Singh
United Kingdom, Cambridge
Strangeways Research Laboratory
Luben, Robert N.
United Kingdom, Cambridge
Strangeways Research Laboratory
Thompson, Deborah J.
United Kingdom, Cambridge
Strangeways Research Laboratory
Baynes, Caroline
United Kingdom, Cambridge
Strangeways Research Laboratory
Pooley, Karen A.
United Kingdom, Cambridge
Strangeways Research Laboratory
Luccarini, Craig
United Kingdom, Cambridge
Strangeways Research Laboratory
Munday, Hannah
United Kingdom, Cambridge
Strangeways Research Laboratory
Perkins, Barbara J.
United Kingdom, Cambridge
Strangeways Research Laboratory
Smith, Paula
United Kingdom, Cambridge
Strangeways Research Laboratory
Pharoah, Paul D.P.
United Kingdom, Cambridge
Strangeways Research Laboratory
Wareham, Nicholas J.
United Kingdom, Cambridge
Strangeways Research Laboratory
d'Adamo, Adamo P.
United Kingdom, Cambridge
Strangeways Research Laboratory
Ponder, Bruce A.J.
United Kingdom, Cambridge
Strangeways Research Laboratory
Dunning, Alison M.
United Kingdom, Cambridge
Strangeways Research Laboratory
Statistics
Citations: 174
Authors: 15
Affiliations: 2
Identifiers
Doi:
10.1093/hmg/ddi398
ISSN:
09646906
e-ISSN:
14602083
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Male
Female