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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Multi-functionalized nanomaterials and nanoparticles for diagnosis and treatment of retinoblastoma
Biosensors, Volume 11, No. 4, Article 97, Year 2021
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Description
Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose, nanotechnology has revolutionized the field of medicine with versatile potential capabilities for both the diagnosis, as well as the treatment, of retinoblastoma via the targeted and controlled delivery of anticancer drugs via binding to the overexpressed retinoblastoma gene. Nanotechnology has also generated massive advancements in the treatment of retinoblastoma based on the use of surface-tailored multi-functionalized nanocarriers; overexpressed receptor-based nanocarriers ligands (folate, galactose, and hyaluronic acid); lipid-based nanocarriers; and metallic nanocarriers. These nanocarriers seem to benchmark in mitigating a plethora of malignant retinoblastoma via targeted delivery at a specified site, resulting in programmed apoptosis in cancer cells. The effectiveness of these nanoplatforms in diagnosing and treating intraocular cancers such as retinoblastoma has not been properly discussed, despite the increasing significance of nanomedicine in cancer management. This article reviewed the recent milestones and future development areas in the field of intraocular drug delivery and diagnostic platforms focused on nanotechnology. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Arshad, Rabia
Pakistan, Islamabad
Quaid-i-azam University
Barani, Mahmood
Iran, Kerman
Daneshgahe Shahid Bahonar-e-kerman
Rahdar, Abbas A.
Iran, Zabol
University of Zabol
Sargazi, Saman
Iran, Zahedan
Zahedan University of Medical Sciences
Cucchiarini, Magali
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Pandey, Sadanand
South Korea, Gyeongsan
Yeungnam University
Kang, Misook
South Korea, Gyeongsan
Yeungnam University
Statistics
Citations: 46
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.3390/BIOS11040097
ISSN:
20796374
Research Areas
Cancer
Genetics And Genomics
Health System And Policy