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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease
Gastroenterology, Volume 158, No. 7, Year 2020
Notification
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Description
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population, and has no approved drug therapy. Although pharmacotherapies are in development, response rates appear modest. The heterogeneous pathogenesis of metabolic fatty liver diseases and inaccuracies in terminology and definitions necessitate a reappraisal of nomenclature to inform clinical trial design and drug development. A group of experts sought to integrate current understanding of patient heterogeneity captured under the acronym nonalcoholic fatty liver disease (NAFLD) and provide suggestions on terminology that more accurately reflects pathogenesis and can help in patient stratification for management. Experts reached consensus that NAFLD does not reflect current knowledge, and metabolic (dysfunction) associated fatty liver disease “MAFLD” was suggested as a more appropriate overarching term. This opens the door for efforts from the research community to update the nomenclature and subphenotype the disease to accelerate the translational path to new treatments. © 2020 AGA Institute
Authors & Co-Authors
Eslam, Mohammed
Australia, Parramatta
The Westmead Institute for Medical Research
Sanyal, Arun Jayant
United States, Richmond
Vcu School of Medicine
George, Jacob A.
Australia, Parramatta
The Westmead Institute for Medical Research
Tiribelli, Claudio
Unknown Affiliation
Kleiner, David E.
Unknown Affiliation
Bugianesi, Elisabetta
Unknown Affiliation
Yki-Jar̈vinen, Hannele
Unknown Affiliation
Gronbaek, H.
Unknown Affiliation
Cortez-Ṕinto, Helena
Unknown Affiliation
Fan, Jiangao
Unknown Affiliation
Valenti, Luca Vittorio Carlo
Unknown Affiliation
Abdelmalek, Manal F.
Unknown Affiliation
Romero-Gómez, Manuel Pérez
Unknown Affiliation
Rinella, Mary Eugenia
Unknown Affiliation
Arrese, Marco A.
Unknown Affiliation
Bédossa, Pierre
Unknown Affiliation
Newsome, P. Noel G.
Unknown Affiliation
Anstee, Quentin M.
Unknown Affiliation
Jalan, Rajiv
Unknown Affiliation
Bataller, Ramón Alberola
Unknown Affiliation
Loomba, Rohit
Unknown Affiliation
Sarin, Shiv Kumar
Unknown Affiliation
Harrison, Stephen A.
Unknown Affiliation
Kawaguchi, Takumi
Unknown Affiliation
Wong, Vincent Wai Sun
Unknown Affiliation
Yilmaz, Yusuf
Unknown Affiliation
Younossi, Zobair M.
Unknown Affiliation
Statistics
Citations: 1,671
Authors: 27
Affiliations: 2
Identifiers
Doi:
10.1053/j.gastro.2019.11.312
ISSN:
00165085
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study