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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Phylogenetic analyses of RPB1 and RPB2 support a middle Cretaceous origin for a clade comprising all agriculturally and medically important fusaria
Fungal Genetics and Biology, Volume 52, Year 2013
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Description
Fusarium (Hypocreales, Nectriaceae) is one of the most economically important and systematically challenging groups of mycotoxigenic phytopathogens and emergent human pathogens. We conducted maximum likelihood (ML), maximum parsimony (MP) and Bayesian (B) analyses on partial DNA-directed RNA polymerase II largest (RPB1) and second largest subunit (RPB2) nucleotide sequences of 93 fusaria to infer the first comprehensive and well-supported phylogenetic hypothesis of evolutionary relationships within the genus and 20 of its near relatives. Our analyses revealed that Cylindrocarpon formed a basal monophyletic sister to a 'terminal Fusarium clade' (TFC) comprising 20 strongly supported species complexes and nine monotypic lineages, which we provisionally recognize as Fusarium (hypothesis F1). The basal-most divergences within the TFC were only significantly supported by Bayesian posterior probabilities (B-PP 0.99-1). An internode of the remaining TFC, however, was strongly supported by MP and ML bootstrapping and B-PP (hypothesis F2). Analysis of seven Fusarium genome sequences and Southern analysis of fusaria elucidated the distribution of genes required for synthesis of 26 families of secondary metabolites within the phylogenetic framework. Diversification time estimates date the origin of the TFC to the middle Cretaceous 91.3. million years ago. We also dated the origin of several agriculturally important secondary metabolites as well as the lineage responsible for Fusarium head blight of cereals. Dating of several plant-associated species complexes suggests their evolution may have been driven by angiosperm diversification during the Miocene. Our results support two competing hypotheses for the circumscription of Fusarium and provide a framework for future comparative phylogenetic and genomic analyses of this agronomically and medically important genus. © 2013.
Authors & Co-Authors
O\'Donnell, Kerry L.
United States, Washington, D.c.
United States Department of Agriculture
Rooney, A. P.
United States, Washington, D.c.
United States Department of Agriculture
Proctor, Robert Henry
United States, Washington, D.c.
United States Department of Agriculture
Brown, Daren W.
United States, Washington, D.c.
United States Department of Agriculture
McCormick, Susan P.
United States, Washington, D.c.
United States Department of Agriculture
Ward, T. J.
United States, Washington, D.c.
United States Department of Agriculture
Frandsen, Rasmus John Normand
Denmark, Lyngby
Technical University of Denmark
Lysøe, Erik
Norway, As
Norsk Institutt for Bioøkonomi
Rehner, Stephen A.
United States, Beltsville
Usda Ars Beltsville Agricultural Research Center
Aoki, Takayuki
Japan, Tsukuba
Institute of Agrobiological Sciences, Naro
Robert, Vincent A.R.G.
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Crous, Pedro Willem
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Groenewald, Johannes Zacharias Ewald
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Kang, Seogchan
United States, University Park
Pennsylvania State University
Geiser, David M.
United States, University Park
Pennsylvania State University
Statistics
Citations: 335
Authors: 15
Affiliations: 7
Identifiers
Doi:
10.1016/j.fgb.2012.12.004
ISSN:
10960937
Research Areas
Genetics And Genomics