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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Association of plasma cholesteryl ester transfer protein activity and polymorphism with coronary artery disease extent in Tunisian type II diabetic patients
Clinical Biochemistry, Volume 38, No. 4, Year 2005
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Description
Introduction: Cholesteryl ester transfer protein (CETP), a key protein in reverse cholesterol transport, has a controversial role in atherosclerosis. Objectives: We investigated CETP activity and polymorphism in Tunisian type II diabetes and its relationship with coronary artery disease (CAD). Design and methods: 173 type II diabetic patients with or without CAD were compared to 67 controls. Results: The HDL cholesterol concentration was low in a Tunisian population. The B1 allele of the CETP gene was associated with a low concentration of HDL cholesterol and was more frequent in Tunisians than in other populations. In type II diabetic patients, the B1 allele was associated with increased prevalence of CAD only in men (OR = 0.357, CI = 0.161-0.791, P = 0.01). The CETP activity increased in type II diabetic patients compared to controls (P = 0.05). Furthermore, the CETP activity was increased in patients with double or triple vessel disease compared to those with single vessel disease (P = 0.025). Conclusions: Our data are in favour of an association between CETP and developing CAD, as well as the extent of CAD. © 2005 The Canadian Society of Clinical Chemists. All rights reserved.
Authors & Co-Authors
Châaba, Raja
Tunisia, Monastir
Faculté de Médecine de Monastir
Hammami, Sonia Ouali
Tunisia, Monastir
Chu Fattouma-bourguiba
Attia, Nebil
Tunisia, Monastir
Faculté de Médecine de Monastir
Smaoui, Maha
Tunisia, Monastir
Faculté de Médecine de Monastir
Masmoudi, Ahmed Slaheddine
Tunisia, Monastir
Faculté de Médecine de Monastir
Mahjoub, Sylvia S.
Tunisia, Monastir
Chu Fattouma-bourguiba
Ben-Hamda, Khaldoun
Tunisia, Monastir
Chu Fattouma-bourguiba
Hammami, M. B.
Tunisia, Monastir
Faculté de Médecine de Monastir
Statistics
Citations: 24
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.clinbiochem.2004.12.011
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male