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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Stem cell transplantation for patients with Fanconi anemia with low-dose cyclophosphamide and antithymocyte globulins without the use of radiation therapy
Bone Marrow Transplantation, Volume 35, No. 5, Year 2005
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Description
In all, 22 patients with confirmed Fanconi anemia (FA) underwent stem cell transplantation (SCT) from HLA-matched, related donors at KFSHRC. Median age at SCT was 7.6 years (range, 2.5-14.6 years). Conditioning regimen consisted of cyclophosphamide (CY) 15 mg/kg/day intravenously (i.v.) for 4 consecutive days, in addition to equine antithymocyte globulins (ATG) given i.v. at 40 mg/kg/day for four doses pre-SCT. No radiation therapy was given. For graft-versus-host disease prophylaxis, we used cyclosporin at the standard doses; ATG was added at 20 mg/kg/dose i.v. on days 2, 4, 6, 8, 10, and 12 post-SCT (total of six doses). All patients engrafted and are alive and transfusion independent with a median follow-up time of 20.2 months (range, 3.3-59 months). One patient however developed a decrease in her WBC and platelet count. Her work-up revealed slightly hypocellular bone marrow, and a series of chimerism studies over 1 year confirmed that she has stable mixed chimerism; she remains transfusion independent. We conclude that low-dose CY without radiation therapy can be used satisfactorily in the conditioning of patients with FA undergoing related SCT. © 2005 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Ayas, Mouhab Fakhreddine
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Jefri, Abdullah Hussain
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Mahr, Mohammed
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Rifai, Samira Z.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Seraihy, Amal S.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Tbakhi, Abdelghani I.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Mustafa, Mahmoud M.
Jordan, Amman
King Hussein Cancer Center
Khairy, Ashraf M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Moussa, Emad A.H.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Iqbal, A.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Shalaby, L.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
El-Solh, Hassan
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 28
Authors: 12
Affiliations: 2
Identifiers
Doi:
10.1038/sj.bmt.1704787
ISSN:
02683369
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study