Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
Nature Communications, Volume 5, Article 3966, Year 2014
Notification
URL copied to clipboard!
Description
The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground stressors. Our results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to hypoxia tolerance, degeneration of vision and progression of photoperiodic perception, tolerance to hypercapnia and hypoxia and resistance to cancer. The remarkable traits of the BMR, together with its genomic and transcriptomic information, enhance our understanding of adaptation to extreme environments and will enable the utilization of BMR models for biomedical research in the fight against cancer, stroke and cardiovascular diseases. © 2014 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Fang, Xiaodong
China, Shenzhen
Bgi-shenzhen
Denmark, Copenhagen
Københavns Universitet
Nevo, Eviatar N.
Israel, Haifa
University of Haifa
Han, Lijuan
China, Shenzhen
Bgi-shenzhen
Levanon, Erez Y.
Israel, Ramat Gan
Bar-ilan University
Zhao, Jing
Denmark, Copenhagen
Københavns Universitet
China, Shenzhen
Bgi-shenzhen
Avivi, Aaron
Israel, Haifa
University of Haifa
Larkin, Denis M.
United Kingdom, Aberystwyth
Institute of Biological, Environmental and Rural Sciences
Jiang, Xuanting
China, Shenzhen
Bgi-shenzhen
Feranchuk, Sergey
Israel, Haifa
University of Haifa
Zhu, Yabing
China, Shenzhen
Bgi-shenzhen
Fishman, Alla
Israel, Haifa
University of Haifa
Feng, Yue
China, Shenzhen
Bgi-shenzhen
Sher, Noa
Israel, Haifa
University of Haifa
Xiong, Zhiqiang
China, Shenzhen
Bgi-shenzhen
Hankeln, Thomas M.A.
Germany, Mainz
Johannes Gutenberg-universität Mainz
Huang, Zhiyong
China, Shenzhen
Bgi-shenzhen
Gorbunova, Vera A.
United States, Rochester
University of Rochester
Zhang, Lu
China, Shenzhen
Bgi-shenzhen
Hong Kong, Hong Kong
City University of Hong Kong
Zhao, Wei
China, Shenzhen
Bgi-shenzhen
Wildman, Derek E.
United States, Detroit
Wayne State University School of Medicine
Xiong, Yingqi
China, Shenzhen
Bgi-shenzhen
Gudkov, Andrei V.
United States, Buffalo
Roswell Park Cancer Institute
Zheng, Qiumei
China, Shenzhen
Bgi-shenzhen
Rechavi, Gideon
Israel, Tel Aviv-yafo
Edmond and Lilly Safra Children's Hospital
Israel, Tel Aviv-yafo
Tel Aviv University
Liu, Sanyang
China, Shenzhen
Bgi-shenzhen
Bazak, Lily
Israel, Ramat Gan
Bar-ilan University
Chen, Jie
China, Shenzhen
Bgi-shenzhen
Knisbacher, Binyamin A.
Israel, Ramat Gan
Bar-ilan University
Lu, Yao
China, Shenzhen
Bgi-shenzhen
Shams, Imad
Israel, Haifa
University of Haifa
Gajda, Krzysztof
United Kingdom, Aberystwyth
Institute of Biological, Environmental and Rural Sciences
Farré, Marta
United Kingdom, Aberystwyth
Institute of Biological, Environmental and Rural Sciences
Kim, Jaebum
South Korea, Seoul
Konkuk University
Lewin, Harris A.
United States, Davis
University of California, Davis
Ma, Jian
United States, Urbana
University of Illinois Urbana-champaign
Band, Mark R.
United States, Urbana
University of Illinois Urbana-champaign
Bicker, Anne
Germany, Mainz
Johannes Gutenberg-universität Mainz
Kranz, Angela
Germany, Mainz
Johannes Gutenberg-universität Mainz
Mattheus, Tobias
Germany, Mainz
Johannes Gutenberg-universität Mainz
Schmidt, Hanno
Germany, Mainz
Johannes Gutenberg-universität Mainz
Seluanov, Andrei
United States, Rochester
University of Rochester
Azpurua, Jorge E.
United States, Rochester
University of Rochester
McGowen, Michael R.
United States, Detroit
Wayne State University School of Medicine
Ben-Jacob, Eshel
Israel, Tel Aviv-yafo
Tel Aviv University
Li, Kexin
Israel, Haifa
University of Haifa
Peng, Shaoliang
China, Changsha
National University of Defense Technology China
Zhu, Xiaoqian
China, Changsha
National University of Defense Technology China
Liao, Xiangke
China, Changsha
National University of Defense Technology China
Li, Shuaicheng
Hong Kong, Hong Kong
City University of Hong Kong
Krogh, Anders
Denmark, Copenhagen
Københavns Universitet
Zhou, Xin
China, Shenzhen
Bgi-shenzhen
Brodsky, Leonid I.
Israel, Haifa
University of Haifa
Wang, Jun
China, Shenzhen
Bgi-shenzhen
Denmark, Copenhagen
Københavns Universitet
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 128
Authors: 53
Affiliations: 17
Identifiers
Doi:
10.1038/ncomms4966
e-ISSN:
20411723
Research Areas
Cancer
Disability
Environmental
Genetics And Genomics
Noncommunicable Diseases