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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: Case Report
Virology Journal, Volume 8, Article 314, Year 2011
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Description
Lassa fever is a neglected tropical disease with a significant impact on the health care system of endemic West African nations. To date, case reports of Lassa fever have focused on laboratory characterisation of serological, biochemical and molecular aspects of the disease imported by infected individuals from Western Africa to the United States, Canada, Europe, Japan and Israel. Our report presents the first comprehensive real time diagnosis and characterization of a severe, hemorrhagic Lassa fever case in a Sierra Leonean individual admitted to the Kenema Government Hospital Lassa Fever Ward. Fever, malaise, unresponsiveness to anti-malarial and antibiotic drugs, followed by worsening symptoms and onset of haemorrhaging prompted medical officials to suspect Lassa fever. A recombinant Lassa virus protein based diagnostic was employed in diagnosing Lassa fever upon admission. This patient experienced a severe case of Lassa hemorrhagic fever with dysregulation of overall homeostasis, significant liver and renal system involvement, the interplay of pro- and anti-inflammatory cytokines during the course of hospitalization and an eventual successful outcome. These studies provide new insights into the pathophysiology and management of this viral illness and outline the improved infrastructure, research and real-time diagnostic capabilities within LASV endemic areas. © 2011 Grove et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3283910/bin/1743-422X-8-314-S1.PPT
https://efashare.b-cdn.net/share/pmc/articles/PMC3283910/bin/1743-422X-8-314-S2.PPT
Authors & Co-Authors
Grove, Jessica N.
United States, New Orleans
Tulane University
Branco, Luis M.
United States, New Orleans
Tulane University
United States, New Orleans
Autoimmune Technologies, Llc
Boisen, Matt L.
United States, Broomfield
Corgenix Medical Corporation
Muncy, Ivana J.
United States, Broomfield
Corgenix Medical Corporation
Henderson, Lee A.
United States, Ithaca
Vybion Inc.
Schieffellin, John S.
United States, New Orleans
Lsuhsc School of Medicine
Robinson, James E.
United States, New Orleans
Lsuhsc School of Medicine
Bangura, James J.
Sierra Leone
Ministry of Health and Sanitation Workplace Health
United States, San Francisco
Global Viral Forecasting Initiative
Fonnie, Mbalu
Sierra Leone
Kenema Government Hospital Lassa Fever Ward
Schoepp, Randal J.
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Hensley, Lisa E.
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Seisay, Alhassan L.
Sierra Leone
Ministry of Health and Sanitation Workplace Health
Fair, Joseph N.
United States, San Francisco
Global Viral Forecasting Initiative
Garry, Robert F.
United States, New Orleans
Tulane University
Statistics
Citations: 45
Authors: 14
Affiliations: 9
Identifiers
Doi:
10.1186/1743-422X-8-314
e-ISSN:
1743422X
Research Areas
Health System And Policy
Study Locations
Sierra Leone