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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Treatment of Burkitt lymphoma in equatorial Africa using a simple three-drug combination followed by a salvage regimen for patients with persistent or recurrent disease
British Journal of Haematology, Volume 158, No. 6, Year 2012
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Description
Prior to the introduction of the International Network for Cancer Treatment and Research (INCTR) protocol INCTR 03-06, survival of patients with Burkitt lymphoma at four tertiary care centres in equatorial Africa was probably no more than 10-20%. The results reported here for 356 patients have demonstrated marked improvement in survival through the use of a uniform treatment protocol consisting of cyclophosphamide, methotrexate, vincristine, and intrathecal therapy, and the introduction of non-cross resistant second-line (salvage) therapy, consisting of ifosfamide, mesna, etoposide and cytarabine, when patients failed to achieve a complete response to first-line therapy or relapsed early. Overall survival rates of 67% and 62% were observed at 1 and 2 years (relapse is rare after 1 year of remission). Of interest was the small impact of cerebrospinal fluid (CSF) and bone marrow involvement on outcome. However, the presence or absence of abdominal involvement clearly defined two prognostic groups. An additional finding was the association between CSF pleocytosis and orbital tumours, suggesting that spread of tumour cells to the central nervous system may sometimes occur via direct involvement of cranial nerves in the orbit. Survival rates may be increased in patients with abdominal involvement by combining first- and second-line therapy, but verification will require a further clinical study. © 2012 Blackwell Publishing Ltd.
Authors & Co-Authors
Ngoma, Twalib Athumani
Unknown Affiliation
Adde, M.
Belgium, Brussels
International Network for Cancer Treatment and Research Inctr
Durosinmi, Muheez Alani
Nigeria, Ife
Obafemi Awolowo University Teaching Hospitals Complex
Githang'a, Jessie N.
Kenya, Nairobi
Kenyatta National Hospital
Aken'Ova, Yetunde A.
Nigeria, Ibadan
University College Hospital, Ibadan
Kaijage, Jane K.
Unknown Affiliation
Adeodou, Oluwagbemiga
Nigeria, Ife
Obafemi Awolowo University Teaching Hospitals Complex
Rajab, Jamilla A.
Kenya, Nairobi
Kenyatta National Hospital
Brown, Biobele Jotham
Nigeria, Ibadan
University College Hospital, Ibadan
Leoncini, L.
Italy, Siena
Università Degli Studi Di Siena
Naresh, Kikkeri N.
United Kingdom, London
Imperial College London
Raphaél, Martine M.
France, Gif-sur-yvette
Université Paris-saclay
Hurwitz, Nina
Belgium, Brussels
International Network for Cancer Treatment and Research Inctr
Switzerland, Basel
Universitat Basel
Scanlan, Patricia
Belgium, Brussels
International Network for Cancer Treatment and Research Inctr
Rohatiner, Ama
Belgium, Brussels
International Network for Cancer Treatment and Research Inctr
Venzon, David J.
United States, Rockville
National Cancer Institute Nci
Magrath, Ian T.
Belgium, Brussels
International Network for Cancer Treatment and Research Inctr
United States, Bethesda
Uniformed Services University of the Health Sciences
Statistics
Citations: 48
Authors: 17
Affiliations: 10
Identifiers
Doi:
10.1111/j.1365-2141.2012.09236.x
ISSN:
00071048
e-ISSN:
13652141
Research Areas
Cancer