Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A novel sickle cell mutation of yet another origin in Africa: the Cameroon type
Human Genetics, Volume 89, No. 3, Year 1992
Notification
URL copied to clipboard!
Description
The sickle cell mutation (βs) arose as at least three independent events in Africa and once in Asia, being termed the Senegal, Benin, Bantu and Indian types respectively. An investigation in Cameroon was carried out to determine whether the atypical sickle genes observed in the neighboring countries are the result of recombination or the presence of a sickle cell mutation of a different genetic origin. It was conducted on 40 homozygous SS patients followed at the Blood Transfusion Center in the capital city of Yaoundé. On 80 βs chromosomes, 13 exhibited a novel polymorphic pattern that was observed three times in the homozygous state. This chromosome contains an AγT gene. The restriction fragment length polymorphism haplotype is different from all the other βs chromosomes in both the 5′ and 3′ regions, but has previously been reported in sporadic cases. The (AT)8(T)5 sequence in the - 500 region of the β gene is specific and different from that of the Senegal, Benin, Bantu or Indian βs genes. All the carriers of this specific chromosome belong to the Eton ethnic group and originate from the Sanaga river valley. This observation strongly argues for yet another independent origin of the sickle cell mutation in Africa, here referred to as the "Cameroon type". The Benin haplotype and a Benin/ Bantu recombinant haplotype have been observed in the other studied populations: Ewondo, Bamiléké, Bassa, Yambassa and Boulou. © 1992 Springer-Verlag.
Authors & Co-Authors
Lapouniéroulie, C.
France, Paris
Hôpital Robert-debré Ap-hp
Dunda, Olga
France, Paris
Laboratoire de Pathologie
Ducrocq, Rolande
France, Paris
Hôpital Robert-debré Ap-hp
Trabuchet, Guy
France, Villeurbanne
Université Claude Bernard Lyon 1
Mony-Lobé, Marcel
Cameroon, Yaounde
Hopital Central de Yaounde
Bodo, Jean Marie
Cameroon, Yaounde
Institut de Recherche Pour le Developpement Cameroon
Carnevale, Pierre J.
Cameroon, Yaounde
Institut de Recherche Pour le Developpement Cameroon
Labié, Dominique
France, Paris
Laboratoire de Pathologie
Elion, Jacques
France, Paris
Hôpital Robert-debré Ap-hp
Krishnamoorthy, Rajagopal
France, Paris
Hôpital Robert-debré Ap-hp
Statistics
Citations: 96
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1007/BF00220553
ISSN:
03406717
e-ISSN:
14321203
Research Areas
Cancer
Genetics And Genomics
Study Locations
Benin
Cameroon
Senegal