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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Integrated dataset of screening hits against multiple neglected disease pathogens
PLoS Neglected Tropical Diseases, Volume 5, No. 12, Article e1412, Year 2011
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Description
New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach. © 2011 Nwaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3243694/bin/pntd.0001412.s001.doc
Authors & Co-Authors
Nwaka, Solomon
Unknown Affiliation
Besson, Dominique
Unknown Affiliation
Ramirez, Bernadette L.
Unknown Affiliation
Maes, Louis J.R.M.
Unknown Affiliation
Matheeussen, An
Unknown Affiliation
Bickle, Quentin D.
Unknown Affiliation
Mansour, Nuha R.N.
Unknown Affiliation
Yousif, Fouad
Unknown Affiliation
Townson, Simon
Unknown Affiliation
Gokool, Suzanne
Unknown Affiliation
Cho-Ngwa, Fidelis
Unknown Affiliation
Samje, Moses
Unknown Affiliation
Misra-Bhattacharya, Shailja
Unknown Affiliation
Murthy, Puvvada Kalpana
Unknown Affiliation
Fakorede, Foluke
Unknown Affiliation
Paris, Jean Marc
Unknown Affiliation
Yeates, Clive
Unknown Affiliation
Ridley, Robert G.
Unknown Affiliation
van Voorhis, Wesley C.E.
Unknown Affiliation
Geary, Timothy G.
Unknown Affiliation
Statistics
Citations: 51
Authors: 20
Affiliations: 13
Identifiers
Doi:
10.1371/journal.pntd.0001412
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Health System And Policy