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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serum proatrial natriuretic peptide does not increase with higher systolic blood pressure in obese men
Heart, Volume 103, No. 2, Year 2017
Notification
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Description
Objective Obese persons have low circulating natriuretic peptide (NP) concentrations. It has been proposed that this 'natriuretic handicap' could play a role in obesity-related hypertension. The normal physiological response of the NP system to an increase in blood pressure (BP) is an increase in NP secretion with concomitant higher circulating NP concentrations. In this study, we investigated whether higher BP would also be related to higher circulating NP concentrations in obese men; furthermore, we verified that BP had affected the hearts of our study participants, by determining left ventricular mass (LVM). Methods We examined 103 obese healthy medication-free men. We measured 24-hour ambulatory BP (ABP). LVM was calculated using the Cornell voltage-duration product method. Fasting serum concentrations of midregional proatrial NP (MR-proANP), a surrogate for active ANP, were measured. Linear regression analysis was used to calculate age-adjusted standardised regression coefficients (β). Results LVM and BP increased across systolic ABP quartiles (mean LVM±SD: 1599.1±387.2 mm ms in first vs 2188.5±551.3 mm ms in fourth quartile, p<0.001; mean systolic ABP±SD: 114.5±4.2 mm Hg in first vs 149.0±7.7 mm Hg in fourth quartile, p<0.001). Systolic ABP was robustly associated with LVM (ß=0.48, p<0.001). Despite evidence of BP-related increases in LVM, serum MR-proANP was negatively associated with systolic ABP (ß=-0.32, p=0.004) and with diastolic ABP (ß=-0.45, p<0.001). Conclusions Contrary to known physiological BP responses, MR-proANP was negatively associated with ABP in our study. This suggests that a low amount of circulating NPs could play a role in the early stage of obesity-related hypertension. © Published by the BMJ Publishing Group Limited.
Authors & Co-Authors
Asferg, Camilla L.
Denmark, Copenhagen
Rigshospitalet
Andersen, Ulrik Bjørn
Denmark, Copenhagen
Rigshospitalet
Linneberg, Allan R.
Denmark, Copenhagen
Research Centre for Prevention and Health
Denmark, Copenhagen
Rigshospitalet
Denmark, Copenhagen
Københavns Universitet
Hedley, P. L.
Denmark, Copenhagen
Statens Serum Institut
Christiansen, Michael
Denmark, Copenhagen
Statens Serum Institut
Goetze, Jens P. Peter
Denmark, Copenhagen
Rigshospitalet
Jeppesen, Jørgen Lykke
Denmark, Copenhagen
Københavns Universitet
Denmark, Hvidovre
Hvidovre Hospital
Statistics
Citations: 4
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1136/heartjnl-2016-309462
ISSN:
13556037
Research Areas
Noncommunicable Diseases
Study Approach
Quantitative
Participants Gender
Male